DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and Wiz

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	XP_036016381.1	Gene:	Wiz / 22404	MGIID:	1332638	Length:	1871	Species:	Mus musculus

Alignment Length:	1266	Identity:	233/1266 - (18%)
Similarity:	378/1266 - (29%)	Gaps:	471/1266 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 QPAAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYMEPEPAQPV-----------VTTSEFIAV 324
            |.|.||...:.....:..:..:.|.|:.|||..:|.:.|....|.           |.::|....
Mouse   239 QVAQPSEWGLHTSASEVATQTWTVNSEASVERLQPLLSPVQTGPYLCELLQEVAGGVDSNEEEEE 303

  Fly   325 EPPPQPNFPVLDHSKPFVCQQCGLAFAREKALVSHTKNHR--------VD-SPFECNQCQEMFWD 380
            ||            ..|.|.:|.:.|..::.|:.|...||        .| :|..|::|...|.:
Mouse   304 EP------------AVFPCIECSIYFKHKEHLLEHMSQHRRAPGQEPPADLAPLACSECGWAFTE 356

  Fly   381 NSSLQEHQKTHQFEESNSEYDPASAEESGSESEADEQLYGE------FYCNECGISFHRQDLLRR 439
            .::|::|.:.||          ||.|:...|.:..:|..|:      ..|::|....:......:
Mouse   357 PTALEQHWQLHQ----------ASREKIIEEIQKLKQFPGDEGREARLQCSKCVFGTNSSRAFMQ 411

  Fly   440 HAKMHCK---PSDQAAVGSNSDVTAGG----DVELA-----KDSSG-HCCNTCGKSFPSALEMLA 491
            |||:|.:   ||.||     ::...||    ||...     .|||| :.|..||.:.||...:..
Mouse   412 HAKLHVRGSLPSRQA-----TEPFRGGSPVLDVSTLVYPSYGDSSGLNTCVHCGFTAPSKSLLRE 471

  Fly   492 HAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKA---------- 546
            |..:                       .|.|..|..|:......|..:.|..:.|
Mouse   472 HTRL-----------------------VHAHHAHWEEVGEAFEDLTSQPCTSQDAYTHSPDTATV 513

  Fly   547 --------LIKHAWDHSREKCHSCSKCG--------KNF-------------------------- 569
                    |:...|..:..........|        :||
Mouse   514 DYFSKSEPLLASVWQENPSGYDPDLAFGPDYQQPGMRNFPLLNSGQQSLGKLAFPSPMASASYSI 578

  Fly   570 -HNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGKLF-----------PCLE 622
             .|:.:...|:....|||.:....:||..:...|::.|   ..|.....|           |.||
Mouse   579 QRNRNKSTVHLQRMEDKSHLWSEEEEEEDEDVVLTSER---DFTPENGAFPPLAIPSLIPQPALE 640

  Fly   623 CGKTF--------GSRSSQQ-----IHVRIHTGERPYGCRYCWKAFAD----------------- 657
            ..:||        .|.:.||     :.:.:....||.......:|...
Mouse   641 LKQTFQDALQAVDASETQQQQLQGMVPIVLMAKLRPQVIAATTRASPQLPPEEPELRSTHPLDFL 705

  Fly   658 ------GGTL-------------RKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVA 703
                  ||:|             .|||.       ..|..||..|:..:.|..|:|.|.:.:.|:
Mouse   706 LLDAPLGGSLGLNTLLEGDPAMALKHEE-------RKCPYCPDRFHNGIGLANHVRGHLNRVGVS 763

  Fly   704 RNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAANKHV 768
            .|                 ::|.|...:....::|  .:..:|.|:.....|...:.||.
Mouse   764 YN-----------------VRHFISAEEVKAIERR--FSFQKKKKKVANFDPGTFSLMRC----- 804

  Fly   769 NGDEEEAIGEGDAEECASDIDFC-------------------DFDVENVDDIFDMAESPKKEKRK 814
                                |||                   ||.:.|    :::..||....::
Mouse   805 --------------------DFCGAGFDTRAGLSSHARAHLRDFGITN----WELTISPINILQE 845

  Fly   815 -RGSAATKADAKPVTNGKAAKPAQDKGKAKPR------YDSTSSQQ-----SDRLWEEKFLHDSQ 867
             ..::|.:....|:.......|.......:||      :..|.::.     .|.|..|:   ::.
Mouse   846 LLATSAAELPPSPLGREPGGPPRSFLTSRRPRLPLTMPFPPTWAEDPGPIYGDGLCSEE---NTM 907

  Fly   868 VALFQIDSLVV------VNDTHLQPA---SSAVSANIPNTRGGSKQQ-GKVQAKSVEGAENLNSS 922
            ||: .:.|.::      |:.|..|.|   ||.|:|.:|:   ||||: ..::|:|:
Mouse   908 VAM-DLGSPLLPKKSLPVSGTLEQVASRLSSKVAAEVPH---GSKQELPDLKAQSL--------- 959

  Fly   923 ATTSDTTFSASTSTASTRSRKRAATTKTASKAPPASNSRPRMIHTEKAKVTKGVGGDSTSSSAKK 987
                 ||.....:...||                                 ||:     ||.|
Mouse   960 -----TTCEVCGACFETR---------------------------------KGL-----SSHA-- 979

  Fly   988 TRSKTYISRTESHNLSLDKSRSSASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMY 1052
                    |:....|.:.:|.||.:.:...||::.....|...:..:|...|:....::
Mouse   980 --------RSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAPLGLTPSLTKKSNSPKE------ 1030

  Fly  1053 DDNLLIDAALLREKTYEKFNPSIVNDLEEILRSP-------LKHERNSRL----RFTSESSTTPQ 1106
               .|..||.....|..|  |.....:.:.::||       |.|..:|.|    ..|...|.||:
Mouse  1031 ---FLAGAARPGLLTLAK--PMDAPAVNKAIKSPPGFSAKGLTHPSSSPLLKKAPLTLAGSPTPK 1090

  Fly  1107 YLHEEEQNL-IKIEPTSP----------------------------------DLREMLEGQQRV- 1135
            ...::...| :...||||                                  :.|:.|....|.
Mouse  1091 NPEDKSPQLSLSPRPTSPKAQWPQSEDEGPLNLTLDSDGGRELDCQLCGAWFETRKGLSSHARAH 1155

  Fly  1136 IAHSG-STPSSSSS---------ARTSRHLRQITANGARAGSKRTTGGVASKTSASPGVVAKKSN 1190
            :.|.| |.|.:..|         .|....:|.....||.|...|......:.:...|...|||:
Mouse  1156 LRHLGVSDPDAKGSPIDVLHGLIRRDGIQIRLPPGRGALAQLGRPPSASTALSLLPPPPPAKKA- 1219

  Fly  1191 TATKVSSSSSSSYLSYGVDSYNVNVPASANNGDVGSGFFSISEVVSAAD---AADAAAKAAAAGK 1252
               |:.:|..:|  .:|                        .:.:|||.   |:|..........
Mouse  1220 ---KLKASGMAS--PWG------------------------KQDLSAAGIFWASDVEPSPLNLSS 1255

  Fly  1253 SERKTRSFECEMCSAIFYDRTQLLEHVHIHI 1283
            ....||...||.|...|.:|..|..|...|:
Mouse  1256 GPEPTRDIRCEFCGEFFENRKGLSSHARSHL 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..186	CDD:275368
		COG5048	326..734	CDD:227381	100/548 (18%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	504..523	CDD:275368	1/18 (6%)
		C2H2 Zn finger	534..554	CDD:275370	5/37 (14%)
		C2H2 Zn finger	562..582	CDD:275370	5/54 (9%)
		C2H2 Zn finger	589..609	CDD:275368	4/19 (21%)
		C2H2 Zn finger	620..640	CDD:275368	7/32 (22%)
		C2H2 Zn finger	648..668	CDD:275368	7/55 (13%)
		zf-H2C2_2	661..685	CDD:290200	8/36 (22%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	709..726	CDD:275371	0/16 (0%)
		Hph	921..>1017	CDD:290417	14/95 (15%)
Wiz	XP_036016381.1	C2H2 Zn finger	310..330	CDD:275368	5/19 (26%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	396..416	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8416
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950