DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	619	Identity:	158/619 - (25%)
Similarity:	229/619 - (36%)	Gaps:	151/619 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 YPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAA 204
            |.||.|.:.|.:|..|..|...|..:.|:.|..||..||:.:.|..|.:.|.       .|....
Human   242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCNECGKTFSQTSSLTCHRRLHT-------GEKPYK 299

  Fly   205 AADSSSAIKFEHQTQRQLDDHYYEQEWPLFQHQQEQENAQQNVHQQHQIVEEGGIQLVASYPDTV 269
            ..:...|..|:...:|....|  .:|.|...::..:...|:::..:|..:..|
Human   300 CEECDKAFHFKSILERHRIIH--TEEKPYKCNECGKTFRQKSILTRHHRLHTG------------ 350

  Fly   270 AQPAAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYMEPEPAQPVVTTSEFIAVEPPPQPNFPV 334

Human   351 ----------------------------------------------------------------- 350

  Fly   335 LDHSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNSSLQEHQKTHQFEESNSE 399
               .||:.|.:||..|:.:.:|..|.:.|..:.|::||:|.:.|...|||..|::.|..|:
Human   351 ---EKPYKCNECGKTFSHKSSLTCHHRLHTGEKPYKCNECGKTFSHKSSLTCHRRLHTGEK---- 408

  Fly   400 YDPASAEESG------SESEADEQLYGE---FYCNECGISFHRQDLLRRHAKMHCKPSDQAAVGS 455
              |...||..      |..|...:::.|   :.|||||.:|.|...|..|.:.|
Human   409 --PYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCHRRRH----------- 460

  Fly   456 NSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRH 520
                         .....:.|..|.|:|.....:..|..||....|:||..||.:|..:..:..|
Human   461 -------------TGEQPYKCEECDKAFRFKSNLERHRRIHTGEKPYKCNECGKTFSRKSYLTCH 512

  Fly   521 LHTRHPSELNANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHR-D 584
             |..|..| .|..|..|||....:.:|..|...||.||.:.|.:|||.|:.:..||||...|. :
Human   513 -HRLHTGE-KAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKRHRRLHSGE 575

  Fly   585 KSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGKLFPCLECGKTFGSRSSQQIHVRIHTGERPYGCR 649
            ....||...:.:.....|..|:..|:...|   :.|.||||||...||...|.|:||||:||.|.
Human   576 NPYKCEDSDKAYSFKSNLEIHQKIHTEENP---YKCNECGKTFSRTSSLTCHRRLHTGEKPYKCE 637

  Fly   650 YCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSE 714
            .|.|||.....|..|.|||||||||.|:.|.:.|::    :.:...||. |......|.|..|.:
Human   638 ECDKAFRVKSNLEGHRRIHTGEKPYKCNECGKTFSR----KSYFICHHR-LHTGEKPYKCNECGK 697

  Fly   715 DLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYK 748
            :.:..:.||.|...|            ||.:.||
Human   698 NFSQKSSLICHHRLH------------TGEKPYK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	7/19 (37%)
		C2H2 Zn finger	170..186	CDD:275368	6/15 (40%)
		COG5048	326..734	CDD:227381	126/417 (30%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	424..444	CDD:275368	9/19 (47%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	504..523	CDD:275368	5/18 (28%)
		C2H2 Zn finger	534..554	CDD:275370	6/19 (32%)
		C2H2 Zn finger	562..582	CDD:275370	9/19 (47%)
		C2H2 Zn finger	589..609	CDD:275368	4/19 (21%)
		C2H2 Zn finger	620..640	CDD:275368	11/19 (58%)
		C2H2 Zn finger	648..668	CDD:275368	8/19 (42%)
		zf-H2C2_2	661..685	CDD:290200	14/23 (61%)
		C2H2 Zn finger	676..696	CDD:275368	3/19 (16%)
		C2H2 Zn finger	709..726	CDD:275371	4/16 (25%)
		Hph	921..>1017	CDD:290417
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	115/498 (23%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	3/19 (16%)
		C2H2 Zn finger	328..348	CDD:275368	2/19 (11%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	468..488	CDD:275368	5/19 (26%)
		C2H2 Zn finger	496..516	CDD:275368	6/20 (30%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	552..572	CDD:275368	9/19 (47%)
		C2H2 Zn finger	580..600	CDD:275368	4/19 (21%)
		C2H2 Zn finger	608..628	CDD:275368	11/19 (58%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		SFP1	<651..737	CDD:227516	27/86 (31%)
		C2H2 Zn finger	664..684	CDD:275368	5/24 (21%)
		C2H2 Zn finger	692..712	CDD:275368	5/19 (26%)
		C2H2 Zn finger	720..740	CDD:275368	158/619 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000