DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cys and CST5

DIOPT Version :9

Sequence 1:	NP_476856.1	Gene:	Cys / 41767	FlyBaseID:	FBgn0004629	Length:	126	Species:	Drosophila melanogaster
Sequence 2:	NP_001891.2	Gene:	CST5 / 1473	HGNCID:	2477	Length:	142	Species:	Homo sapiens

Alignment Length:	133	Identity:	25/133 - (18%)
Similarity:	55/133 - (41%)	Gaps:	26/133 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCILGLVLVSLIATQAADEQVVGG---VSQLEGNSRKEALELLDATLAQLATGDGPSYKAINVTS 68
            |.:|..::|::..:.:|..:.:.|   .:.|...|.:.||:...:...::...|....:.:.|.:
Human     9 LLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQCALDFAISEYNKVINKDEYYSRPLQVMA 73

  Fly    69 VTGQVVAGSLNTY-------------EVELDNG--------SDKKQCTVKIWTQPWLKENGTNIK 112
            ...|:| |.:|.|             :..|||.        .:::.|:.:|...|| ::..:.:.
Human    74 AYQQIV-GGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCSFQINEVPW-EDKISILN 136

  Fly   113 IKC 115
            .||
Human   137 YKC 139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cys	NP_476856.1	CY	26..115	CDD:214484	19/112 (17%)
CST5	NP_001891.2	CY	29..139	CDD:214484	19/111 (17%)
CST5	NP_001891.2	Secondary area of contact	70..74		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CZYG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565344at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910