DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and PDE5A

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001074.2	Gene:	PDE5A / 8654	HGNCID:	8784	Length:	875	Species:	Homo sapiens

Alignment Length:	918	Identity:	370/918 - (40%)
Similarity:	521/918 - (56%)	Gaps:	127/918 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIE 178
            ||..|...|.|..||.:        .|:|.|.|....::..:....:...:|..|.::..  |.|
Human     6 PSFGQQRQQQQPQQQKQ--------QQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAW--FAE 60

  Fly   179 NRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLP-------ECRRHL---------- 226
              :.|..|.....:.....:.|..:|| |||  :::||...|       |..|.|
Human    61 --RVHTIPVCKEGIRGHTESCSCPLQQ-SPR--ADNSAPGTPTRKISASEFDRPLRPIVVKDSEG 120

  Fly   227 --------------------MDLDEGE---LFMELIRDVANELDIDVLCHKILVNVGLLTHADRG 268
                                .|.|||:   ..:||::|:::.||:..|||||.:::..|..|||.
Human   121 TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRY 185

  Fly   269 SLFL-AKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAY 332
            |||| .:.:..:|:|:::||||.:.:.|::    .|...|.:.:..||.|.||...:.:|||:||
Human   186 SLFLVCEDSSNDKFLISRLFDVAEGSTLEE----VSNNCIRLEWNKGIVGHVAALGEPLNIKDAY 246

  Fly   333 KDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNG-CMEFDEHDVEIFRRYLTFCG 396
            :|.|||.|:|..|||||.:||||||.|:..:::||||.|||.:| ...|.|.|.:.|..||.|||
Human   247 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCG 311

  Fly   397 IGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDC 461
            |.:.||||:|.|:.|.:|||:||:||..|||||.:||.::.||.......::.::|::|:||.||
Human   312 IVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDC 376

  Fly   462 CEA----SHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSS 522
            .::    .|:|         .....||:|:...:...|:...::
Human   377 SDSFSSVFHME---------CEELEKSSDTLTREHDANKINYMY--------------------- 411

  Fly   523 STLAQIAQFVATTGQTVNICDV-----IEWVRDH----NQIRAEDEIDSTQAILCMPIMNAQK-K 577
                  ||:|..|.:.:||.||     ..|..::    ||       ...:::||.||.|.:| |
Human   412 ------AQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQ-------QCIRSLLCTPIKNGKKNK 463

  Fly   578 VIGVAQLINK-----ANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSY 637
            ||||.||:||     ....||..:|....|||.|||||||.||||||...:.||||.|.||.|||
Human   464 VIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSY 528

  Fly   638 HATASQDQT---EKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYD 699
            ||:|::::|   :.|...|:..|::..:..|:|:||||.|.:|....:|||...|||..||:.::
Human   529 HASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHE 593

  Fly   700 VLCRWVLSVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHR 763
            |||||:|||:||||. |.|||||||.|.||.|||.||.||::..:||||||.||:|.|.||||||
Human   594 VLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 658

  Fly   764 GTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILST 828
            |.||::..::|.|||.||..|.|||||||||:|||||.||.|...||.|:|::.:|.::.|||:|
Human   659 GVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILAT 723

  Fly   829 DLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFD 893
            |||:|.|:|..|.||:...:|:.:...:|:|...|:|||||:|||.|||.:|.::|:|||.||||
Human   724 DLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFD 788

  Fly   894 QGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNW 958
            |||.|:.:||.:|..:|:||:|:::|.|||||||.|||.||..|........||.:|..:||:.|
Human   789 QGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKW 853

  Fly   959 QDLAEKVE 966
            |.|||:.|
Human   854 QALAEQQE 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	73/160 (46%)
		GAF	431..619	CDD:214500	59/206 (29%)
		PDEase_I	717..950	CDD:278654	129/232 (56%)
PDE5A	NP_001074.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..102		9/26 (35%)
		GAF	164..321	CDD:214500	73/160 (46%)
		GAF	347..513	CDD:214500	61/208 (29%)
		PDEase_I	612..847	CDD:278654	130/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1695
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830