DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and PDE8B

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001336678.1	Gene:	PDE8B / 8622	HGNCID:	8794	Length:	906	Species:	Homo sapiens

Alignment Length:	1023	Identity:	206/1023 - (20%)
Similarity:	378/1023 - (36%)	Gaps:	203/1023 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GAASPVEMSTTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGA-VPGPGSGAIPASSSSGN 73
            |.|..:.:|.:.......:..|||...|     |::|.......||. |....:.|||.|.:||
Human     2 GCAPSIHVSQSGVIYCRDSDESSSPRQT-----TSVSQGPAAPLPGLFVQTDAADAIPPSRASG- 60

  Fly    74 QVKLEHHHRQSNNNRPAVTN-RSSETKLMTPTGS-SSSPSQSPSQT-----------QASIQTQT 125
                          .|:|.. |.:.|:|    || ||:.|.:|:.|           .|..:|||
Human    61 --------------PPSVARVRRARTEL----GSGSSAGSAAPAATTSRGRRRHCCSSAEAETQT 107

  Fly   126 SQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTS 190
            ........||.|:|...|.:|.....::..:.|    .|..|..|:  |:.|:......:....|
Human   108 CYTSVKIGASQTSSNLRVKKVDAYLHQQVSSAE----VRIGPMRLT--QDPIQVLLIFAKEDSQS 166

  Fly   191 DLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKI 255
            |.|  |.|......:   .:::.:..|:| ||     .||:....:.:........|.:.:|..|
Human   167 DGF--WWACDRAGYR---CNIARTPESAL-EC-----FLDKHHEIIVIDHRQTQNFDAEAVCRSI 220

  Fly   256 LVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTA----LKDAVTRASAEEIIIPFGIGIA 316
            ..     |:....::.||        :|:::.|..::.:    |.....|...|.         :
Human   221 RA-----TNPSEHTVILA--------VVSRVSDDHEEASVLPLLHAGFNRRFMEN---------S 263

  Fly   317 GMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCME-- 379
            .::|...::|.|:..          ::::.:|..|      ||         .:....:.|.|
Human   264 SIIACYNELIQIEHG----------EVRSQFKLRA------CN---------SVFTALDHCHEAI 303

  Fly   380 ---FDEHDVE----IFRRYLTFCGIGIQNAQLFEMSVQEYRRNQIL---------------LNLA 422
               .|:|.::    .|.|.:.:....:...:|.::...:..|..:|               :..|
Human   304 EITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYA 368

  Fly   423 RSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADS 487
            |....:.......:|.::.:..::    |..|.|..| ||...:.::|.:........:.....|
Human   369 RRKSGDSIQQHVKITPVIGQGGKI----RHFVSLKKL-CCTTDNNKQIHKIHRDSGDNSQTEPHS 428

  Fly   488 FEEKKMRNRFTVLFELGGEYQAA----NVSRPSVSELSSSTL-AQIAQFVATTGQTVNICDVIEW 547
            |..|..|.....:..:......|    |...||::.:.|.|: |.|.:          :.::|..
Human   429 FRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITK----------VINIINA 483

  Fly   548 VRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGI 612
            .::::.:...:.:|....||            ...:|.:...|....|...|     .:..||
Human   484 AQENSPVTVAEALDRVLEIL------------RTTELYSPQLGTKDEDPHTS-----DLVGGL-- 529

  Fly   613 HNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDV---IAEAESYNLYSFTFTDFELVD 674
                |.:...:|...:.|..:  :.|.:.|.........||   |::... |..|:.|..|||..
Human   530 ----MTDGLRRLSGNEYVFTK--NVHQSHSHLAMPITINDVPPCISQLLD-NEESWDFNIFELEA 587

  Fly   675 DDTCRAV----LRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAML 734
            ....|.:    |::|.:..:..........|..|...:..||.... |||..||.:|.......|
Human   588 ITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFL 652

  Fly   735 KTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMIL 798
            ...:::..:..|:.:..|:|...||:||.|..|:|.....|.||:||. |:.:|.||......:.
Human   653 GKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLT 717

  Fly   799 NSEGN-NIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELV----------ENGEFDWQ 852
            ..:.. |||:.:....||::.:.:...:|:|::..:|:..|.|:..:          .:.|.:..
Human   718 VKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPA 782

  Fly   853 GE---EKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRER 914
            |:   |.:.|:..||:...||:...:|.::..:.|..:::|:|.|.|.||.|  ..||.|...:|
Human   783 GKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQ--GLPVVMPVFDR 845

  Fly   915 KD-ELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDL 961
            .. .:||.|:.|||.....::.. .|.|..:..|.:...:|.::|:.|
Human   846 NTCSIPKSQISFIDYFITDMFDA-WDAFAHLPALMQHLADNYKHWKTL 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	25/171 (15%)
		GAF	431..619	CDD:214500	31/192 (16%)
		PDEase_I	717..950	CDD:278654	66/248 (27%)
PDE8B	NP_001336678.1	PDE8	1..47	CDD:285793	12/49 (24%)
		PAS_9	301..398	CDD:315989	13/100 (13%)
		PDEase_I	635..882	CDD:306695	66/249 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920