DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde2a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001137319.1	Gene:	Pde2a / 81743	RGDID:	620965	Length:	935	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	277/949 - (29%)
Similarity:	445/949 - (46%)	Gaps:	141/949 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 HHHRQSNNNRPAVTNRSSETKLMTPTGSSSSPSQSPSQTQASI------QTQTSQQDRLAKASTT 137
            |...|....|.||.:|    |.::..|  ..||....:..|.:      .||......|.|.:.|
  Rat    97 HELPQEGKIREAVISR----KRLSCDG--LGPSDLLGKPLARLVAPLAPDTQVLVIPLLDKETGT 155

  Fly   138 ASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPT 202
            .:...:....:|.:.:.::.:  :.|:....||.|:|. ::.|:|....:.::|         |:
  Rat   156 VAAVILVHCGQLSDSEEQSLQ--VVEKHALVALQRVQA-LQQRRPEAVQNTSAD---------PS 208

  Fly   203 VQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADR 267
            ..||..:..:......|..| ..|.|||...|.::::|.:..|                 |.|..
  Rat   209 EDQKDEKGYTAHDRKILQLC-GELYDLDATSLQLKVLRYLQQE-----------------TQATH 255

  Fly   268 GSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAY 332
            ..|.|.  :..|..|..|:..           .:...||:..|..:|..|.|.:.||.|.:|:..
  Rat   256 CCLLLV--SEDNLQLSCKVIG-----------EKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLT 307

  Fly   333 KD------ARFNCEIDLKTGYKTNAILCMPICNYEGD-IIGVAQIINKTNGCMEFDEHDVEIFRR 390
            .|      ....||:        .|:||:|:.:...| ::.:|...||..|.. |.:.|....:.
  Rat   308 SDDVQQLQNMLGCEL--------RAMLCVPVISRATDQVVALACAFNKLGGDF-FTDEDERAIQH 363

  Fly   391 YLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVF 455
            ...:.|..:.:...|:...:.....|.||.:|:::|...:::..|:.:|:||||.|...|.||||
  Rat   364 CFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVF 428

  Fly   456 LVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSEL 520
            |:|.:        :::.|                          :|: ||      |......|:
  Rat   429 LLDQN--------ELVAK--------------------------VFD-GG------VVDDESYEI 452

  Fly   521 SSSTLAQIAQFVATTGQTVNICDV------IEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVI 579
            .......||..||||||.:||.|.      ...|.|....|       |:.|||.||.|..::||
  Rat   453 RIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR-------TRNILCFPIKNENQEVI 510

  Fly   580 GVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQD 644
            |||:|:||.||..|:..|..:..||:|:||:.|.::.:|:...:...:..:|.|.:.||...|.|
  Rat   511 GVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 575

  Fly   645 QTEKLTQDVI--AEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLS 707
            :..||..|.|  ..|...|..:||:|...|.:|||..|:|.|....|.::.::|....|.|:.|.
  Rat   576 EYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 640

  Fly   708 VRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTK 772
            |:|.||...||||.||.:|:...:.:.|..::..::.|:||..|.::|:|||||||||||:||..
  Rat   641 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 705

  Fly   773 TESPLAILYTT--STMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFK 835
            ::|.||.||::  |.||.|||.|.:.|||:.|.|||...|.:||:.::..:...||:||||.:.:
  Rat   706 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLR 770

  Fly   836 KRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKL 900
            ......::.|.| :|...::...||..::||:||:|...|.|:...|:|:|:..|||.||||||
  Rat   771 IFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK- 833

  Fly   901 QLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKV 965
            .:..:|:.||||| |..:|::|:.|::.|.:|:|::|.|.||....|||....||.:|..::.|.
  Rat   834 AMGNRPMEMMDRE-KAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 897

  Fly   966 EM-GLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLN 1003
            .: ||.  .::::|...||:      |:.|::.|...:|
  Rat   898 TIRGLP--SNNSLDFLDEEY------EVPDLDVTRAPVN 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	32/165 (19%)
		GAF	431..619	CDD:214500	59/193 (31%)
		PDEase_I	717..950	CDD:278654	97/234 (41%)
Pde2a	NP_001137319.1	GAF	235..382	CDD:214500	37/185 (20%)
		GAF	404..553	CDD:214500	60/196 (31%)
		PDEase_I	650..883	CDD:278654	98/235 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820