DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and Pde1a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_110498.1	Gene:	Pde1a / 81529	RGDID:	68329	Length:	542	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	127/483 - (26%)
Similarity:	214/483 - (44%)	Gaps:	82/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 GIHNTQMYENACKLMAKQKVALECLSYHAT--ASQDQTEKLTQDVIAEAESYNLYSFTFTDFELV 673
            ||...:||.....::.        |:|.|.  .:..:.:|.:.||.|..|:...:|..|..:||
  Rat   128 GIFVERMYRKNYHMVG--------LTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYEL- 183

  Fly   674 DDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM-FAMLK 735
                       |...:|:::|:||...|..:..::...|...|  |||..||.:|.||: :.||.
  Rat   184 -----------FTSNDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLH 237

  Fly   736 TGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILN 799
            ||.| .::|:||||.::.|...||.:|.||.|.|..:|.|.:||||. .|.:|:||......::.
  Rat   238 TGIM-HWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301

  Fly   800 SEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKD--LLCG 862
            .|..||...||.:|:|.:...|...:|:||::.:|::       ::|.....|..|..|  ....
  Rat   302 EEEMNILVNLSKDDWRDLRNLVIETVLATDMSGHFQQ-------IKNIRSSLQQPEGIDRAKTMS 359

  Fly   863 MMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDEL-PKMQVGF 925
            :::.|.|:|..||.|::.::....:.:|||.|||.| :|.|...|:.    :||..: .:.|:||
  Rat   360 LILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC----DRKSTMVAQSQIGF 420

  Fly   926 IDVICLPLYRVLCD-TFPWITPLY-EGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACA 988
            ||.|..|.:.:|.| |...:.||. |.:.....|:...:....:|.
  Rat   421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMIGF------------------- 466

  Fly   989 DEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDG 1053
              .:.|......|..|.      |:.::.|::..|...|         |:.::.|...:..:.:.
  Rat   467 --HVADALRRSNTKGCM------SDGTYAPDYSLSAVDL---------KSFKNNLVDIIQQNKER 514

  Fly  1054 SKPKTSLKLLESHV-SEDMDDK-SPTSP 1079
            .|...:...|:.|. |||:::| :.|.|
  Rat   515 WKELAAQGELDLHKNSEDLEEKHADTHP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	3/7 (43%)
		PDEase_I	717..950	CDD:278654	82/240 (34%)
Pde1a	NP_110498.1	PDEase_I_N	77..133	CDD:285672	2/4 (50%)
Pde1a	NP_110498.1	PDEase_I	218..434	CDD:278654	78/227 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010