Protein Alignment Pde6 and pde5a

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_012821480.2
• Gene: pde5a / 780273
• XenbaseID: XB-GENE-479676
• Length: 943
• Species: Xenopus tropicalis
• Alignment Length: 985
• Identity: 388/985 - (39%)
• Similarity: 534/985 - (54%)
• Gaps: 166/985 - (16%)

  Fly    11 AASPVEMSTTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQV 75
            ||:| ||..|........:|:.|..:.:..|..|..|....|  .|........||||...|
 Frog    84 AAAP-EMGDTPEPQVENWAATHSATVNSSCNAHACCTLQEMV--NAWFAERVHTIPASKEQG--- 142

  Fly    76 KLEHHHRQSNNNRPAVTNRSSETKLMTPTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQ 140
                     .||                  |.|:|       |......|:|...:.|.|  ||:
 Frog   143 ---------KNN------------------SESNP-------QVCYSENTTQGTPVRKIS--ASE 171

  Fly   141 QDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQ 205
                            |::.|......:::..|:...::.|....|
 Frog   172 ----------------FDRPLRPIVVKDSVGTLKFLSDSEKKELMP------------------- 201

  Fly   206 KSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSL 270
            ..|.|||.:.    .:|.|          .:||::|:::.||:..|||||.:::..|..|||.||
 Frog   202 LQPPSLSRAG----DQCSR----------LLELVKDISSHLDVTTLCHKIFLHIHELIAADRYSL 252

  Fly   271 FL-AKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKD 334
            || .:.:...|:||::||||.:.|    .|.:||...|.:.:..||.|.||:..|.:|||:||:|
 Frog   253 FLVCEDSSNKKFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQD 313

  Fly   335 ARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCM-EFDEHDVEIFRRYLTFCGIG 398
            :|||.|:|..|||||.:||||||.|:..:::||||.|||.:|.. .|.:.|.:.|..||.||||.
 Frog   314 SRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGSNGTFTDQDEKDFAAYLAFCGIV 378

  Fly   399 IQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDC-- 461
            :.||||:|.|:.|.||||:||:||..|||||.:||.::.||.......::.:||::|:||.|.
 Frog   379 LHNAQLYETSLLENRRNQVLLDLATLIFEEQQSLEVILKKIAATILSFMQAQRCTIFIVDEDSPD 443

  Fly   462 -------CEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSE 519
                   .|:..||              :|||:.:.               ||..:.::
 Frog   444 TFSSVFHMESDELE--------------ESADAVKR---------------EYDVSKMN------ 473

  Fly   520 LSSSTLAQIAQFVATTGQTVNICDVIE-----WVRDHNQIRAEDEIDSTQAILCMPIMNAQK-KV 578
                  ...||:||.|.:.:||.|:.:     |...:.    |......|::||.||.||:| ||
 Frog   474 ------YMYAQYVANTMEAINIPDICKDTRFPWTNGNE----EKNFKHIQSLLCSPIKNAKKNKV 528

  Fly   579 IGVAQLINKANG-----VPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYH 638
            |||.||:||.:.     ..|..:|....|||||||||||.||||:|...:.||||.|.||.||||
 Frog   529 IGVCQLVNKVDENSGKIKAFNKNDEQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMVTLEILSYH 593

  Fly   639 ATASQDQTEKL---TQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDV 700
            |:|::::|.:|   ...::..|:|..|..|.|:||||.|.:|..|..|||...|||..||:.|:.
 Frog   594 ASAAEEETMELQVTAGAIVPSAQSLKLTEFYFSDFELSDMETTLATSRMFTDLNLVQTFQMKYET 658

  Fly   701 LCRWVLSVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRG 764
            ||||:|||:||||. |.|||||||.|.||.|||.|:|||::..:.|||||.|::|.|.|||||||
 Frog   659 LCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALRTGKIQGKLNDLEILALMIATLSHDLDHRG 723

  Fly   765 TNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTD 829
            .||:|..::|.|||.||..|.||:||||||:|||||:||.|...||.:||::|:|.::.|||:||
 Frog   724 VNNSFIQRSEHPLAQLYCHSIMENHHFDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATD 788

  Fly   830 LAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQ 894
            ||:|.|:|:.|.|||...:|.|....:|:|...|:|||||:|||.|||.||.::|:|||.||:||
 Frog   789 LALYIKRRSDFFELVNKKKFKWDDPSQKELFLAMLMTACDLSAITKPWPVQQRIAELVASEFYDQ 853

  Fly   895 GDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQ 959
            ||.|:.:||.:|:.:|:||:||::|.|||||||.:||.||..|........||.:|...||:.||
 Frog   854 GDKERRELNIEPIDLMNREKKDKIPSMQVGFIDAVCLELYEALTQISESCYPLLDGCQRNRQMWQ 918

  Fly   960 DLAEKVEMGL 969
            .|||:.|..|
 Frog   919 ILAEQQEKNL 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	76/160 (48%)
		GAF	431..619	CDD:214500	62/207 (30%)
		PDEase_I	717..950	CDD:459723	130/232 (56%)
pde5a	XP_012821480.2	GAF	229..386	CDD:214500	76/160 (48%)
		GAF	412..577	CDD:214500	63/209 (30%)
		PDEase_I	676..910	CDD:459723	130/233 (56%)