DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde5a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_012821480.2	Gene:	pde5a / 780273	XenbaseID:	XB-GENE-479676	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	985	Identity:	388/985 - (39%)
Similarity:	534/985 - (54%)	Gaps:	166/985 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AASPVEMSTTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQV 75
            ||:| ||..|........:|:.|..:.:..|..|..|....|  .|........||||...|
Frog    84 AAAP-EMGDTPEPQVENWAATHSATVNSSCNAHACCTLQEMV--NAWFAERVHTIPASKEQG--- 142

  Fly    76 KLEHHHRQSNNNRPAVTNRSSETKLMTPTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQ 140
                     .||                  |.|:|       |......|:|...:.|.|  ||:
Frog   143 ---------KNN------------------SESNP-------QVCYSENTTQGTPVRKIS--ASE 171

  Fly   141 QDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQ 205
                            |::.|......:::..|:...::.|....|
Frog   172 ----------------FDRPLRPIVVKDSVGTLKFLSDSEKKELMP------------------- 201

  Fly   206 KSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSL 270
            ..|.|||.:.    .:|.|          .:||::|:::.||:..|||||.:::..|..|||.||
Frog   202 LQPPSLSRAG----DQCSR----------LLELVKDISSHLDVTTLCHKIFLHIHELIAADRYSL 252

  Fly   271 FL-AKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKD 334
            || .:.:...|:||::||||.:.|    .|.:||...|.:.:..||.|.||:..|.:|||:||:|
Frog   253 FLVCEDSSNKKFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQD 313

  Fly   335 ARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCM-EFDEHDVEIFRRYLTFCGIG 398
            :|||.|:|..|||||.:||||||.|:..:::||||.|||.:|.. .|.:.|.:.|..||.||||.
Frog   314 SRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGSNGTFTDQDEKDFAAYLAFCGIV 378

  Fly   399 IQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDC-- 461
            :.||||:|.|:.|.||||:||:||..|||||.:||.::.||.......::.:||::|:||.|.
Frog   379 LHNAQLYETSLLENRRNQVLLDLATLIFEEQQSLEVILKKIAATILSFMQAQRCTIFIVDEDSPD 443

  Fly   462 -------CEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSE 519
                   .|:..||              :|||:.:.               ||..:.::
Frog   444 TFSSVFHMESDELE--------------ESADAVKR---------------EYDVSKMN------ 473

  Fly   520 LSSSTLAQIAQFVATTGQTVNICDVIE-----WVRDHNQIRAEDEIDSTQAILCMPIMNAQK-KV 578
                  ...||:||.|.:.:||.|:.:     |...:.    |......|::||.||.||:| ||
Frog   474 ------YMYAQYVANTMEAINIPDICKDTRFPWTNGNE----EKNFKHIQSLLCSPIKNAKKNKV 528

  Fly   579 IGVAQLINKANG-----VPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYH 638
            |||.||:||.:.     ..|..:|....|||||||||||.||||:|...:.||||.|.||.||||
Frog   529 IGVCQLVNKVDENSGKIKAFNKNDEQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMVTLEILSYH 593

  Fly   639 ATASQDQTEKL---TQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDV 700
            |:|::::|.:|   ...::..|:|..|..|.|:||||.|.:|..|..|||...|||..||:.|:.
Frog   594 ASAAEEETMELQVTAGAIVPSAQSLKLTEFYFSDFELSDMETTLATSRMFTDLNLVQTFQMKYET 658

  Fly   701 LCRWVLSVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRG 764
            ||||:|||:||||. |.|||||||.|.||.|||.|:|||::..:.|||||.|::|.|.|||||||
Frog   659 LCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALRTGKIQGKLNDLEILALMIATLSHDLDHRG 723

  Fly   765 TNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTD 829
            .||:|..::|.|||.||..|.||:||||||:|||||:||.|...||.:||::|:|.::.|||:||
Frog   724 VNNSFIQRSEHPLAQLYCHSIMENHHFDQCLMILNSQGNQILSGLSVQDYKTVLKMIKQAILATD 788

  Fly   830 LAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQ 894
            ||:|.|:|:.|.|||...:|.|....:|:|...|:|||||:|||.|||.||.::|:|||.||:||
Frog   789 LALYIKRRSDFFELVNKKKFKWDDPSQKELFLAMLMTACDLSAITKPWPVQQRIAELVASEFYDQ 853

  Fly   895 GDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQ 959
            ||.|:.:||.:|:.:|:||:||::|.|||||||.:||.||..|........||.:|...||:.||
Frog   854 GDKERRELNIEPIDLMNREKKDKIPSMQVGFIDAVCLELYEALTQISESCYPLLDGCQRNRQMWQ 918

  Fly   960 DLAEKVEMGL 969
            .|||:.|..|
Frog   919 ILAEQQEKNL 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	76/160 (48%)
		GAF	431..619	CDD:214500	62/207 (30%)
		PDEase_I	717..950	CDD:278654	130/232 (56%)
pde5a	XP_012821480.2	GAF	229..386	CDD:214500	76/160 (48%)
		GAF	412..577	CDD:214500	63/209 (30%)
		PDEase_I	676..911	CDD:395177	131/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		otm48017
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.030