DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde9ab

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_700447.5	Gene:	pde9ab / 571737	ZFINID:	ZDB-GENE-210629-1	Length:	518	Species:	Danio rerio

Alignment Length:	526	Identity:	136/526 - (25%)
Similarity:	241/526 - (45%)	Gaps:	75/526 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 SADSFEEKKMRNRFTVLFELGGEYQAANVSRP----SVSEL--SSSTLAQ--IAQFVATTGQTVN 540
            |:.|:..|      |:..::.|:.|....||.    .:.:|  |||.:|:  ....:.:.|..::
Zfish     4 SSSSYTPK------TIYLDVDGKVQRVIFSRHCSPCDIRDLLCSSSNIARNTAVLLIDSEGALIS 62

  Fly   541 ICDV--------IEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSD 597
            |...        :..|..|:..:.|::.|..|.:|..           ||:...:|..:....::
Zfish    63 IDPTMPANTPNNLYKVMSHSTNQGEEKEDMFQNVLSQ-----------VAEQFTRAFRISELKTE 116

  Fly   598 A----SIFEAFAIFCGLGIHNTQMYENACKLM------AKQKVALECLSYHATASQDQTEKLT-- 650
            .    ::.|......||.:...:..:|..|.:      ...:|...| .|:.|   |..:||:
Zfish   117 VTNRLAMLEKRVELEGLKVVEIEKCKNDLKKLKDEMTSGSMRVNCNC-KYNFT---DDGKKLSPR 177

  Fly   651 QDVIAEAESYNLYSF-----------TFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRW 704
            :||    .:|..|:.           ||..:....::....:..|:....||.:|.:....|.||
Zfish   178 RDV----PNYPKYTLSQETIDALKKPTFDVWHWEHNEMLSCLEYMYHDLGLVKEFNMNPITLKRW 238

  Fly   705 VLSVRKNYRPVKYHNWRHALNVAQTMFAMLK-TGKMERF-MTDLEILGLLVACLCHDLDHRGTNN 767
            :|::::|||...:||:||...|:|.|:.|:. .|..:|. |||:.|  |:.|.:||||||.|.||
Zfish   239 LLAIQENYRDNPFHNFRHCFCVSQMMYGMIHLCGLQDRLTMTDMCI--LMTAAVCHDLDHPGYNN 301

  Fly   768 AFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLA 831
            .:|....:.||:.|. .|.:|:||......||:....|||..:.||.::.:.:.:.:.||:||:|
Zfish   302 TYQINARTELAVRYNDISPLENHHCAVAFQILSMPECNIFANIEPESFKQIRQAIITLILATDMA 366

  Fly   832 MYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGD 896
            .:.:..::|.:.|:|  ||...||....|..:::..||:|...:|.||.......:.:|:|.|.|
Zfish   367 KHGEILDSFKQKVDN--FDCTNEEHVKSLKMVLIKCCDISNEVRPTEVAEPWVDCLLEEYFMQSD 429

  Fly   897 LEKLQLNTQPVA-MMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQD 960
            .||.:  ..||| .|||::..: |..|:|||..:.:|::..:...||.|..:....|.:.|:..:
Zfish   430 REKSE--GLPVAPFMDRDKVTK-PTAQIGFIKFVLIPMFETVMKLFPQIEEIMVQPLRDSRDHYE 491

  Fly   961 LAEKVE 966
            ..:::|
Zfish   492 ELKQIE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	27/154 (18%)
		PDEase_I	717..950	CDD:278654	80/236 (34%)
pde9ab	XP_700447.5	PDEase_I	251..481	CDD:278654	80/236 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920