Protein Alignment Pde6 and pde8b

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_009293455.1
• Gene: pde8b / 571011
• ZFINID: ZDB-GENE-091117-3
• Length: 874
• Species: Danio rerio
• Alignment Length: 1036
• Identity: 196/1036 - (18%)
• Similarity: 353/1036 - (34%)
• Gaps: 283/1036 - (27%)

  Fly    13 SPVEMSTTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVKL 77
            || ..:||.|...|||           .:...|.|.|....|..:      |.....:..|
Zfish    25 SP-HQTTTISQGTATT-----------LHGLFIKTDAADTIPSVI------AYQTRHTRTN---- 67

  Fly    78 EHHHRQSNNNRPAVTNRSSETKLMTPTGSSSSP-------SQSPSQTQASIQTQTSQQD------ 129
            .|..|:.|:.....|...::|...:...|.:..       |..|.|.......:.||.|
Zfish    68 SHRERRENSGGQMCTEAETQTSCTSVKVSGAEDRLGPMRLSHEPIQVLLVFAKEDSQSDAFWWAC 132

  Fly   130 -------RLAKASTTASQQDVD---EVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHK 184
                   .:|:...:|.:..:|   |:..:....|..||        .||:.|:   |...|..:
Zfish   133 ERAAFRCNIARTPESALECFLDKHHEIVIIDGRHPRYFE--------AEAICRM---IRATKLSE 186

  Fly   185 R-------PSVTSDLFQQWMAASPTVQQK-SPRSLSNSSASSLPECRRHLMDLDEGELFMEL-IR 240
            .       |...||  |:..:..|.:... |.|.|.|||.|:   |...|:.|:.||:..:. :|
Zfish   187 HTVILAVMPQTPSD--QEEPSVLPLLSAGFSRRYLENSSVSA---CYNELIQLEHGEVRAQFKLR 246

  Fly   241 DVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDA--VTRAS 303
                      .|:.:.                                    |||:..  ....|
Zfish   247 ----------ACNAVF------------------------------------TALEQCQEAVEIS 265

  Fly   304 AEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIG-- 366
            :|:.:|.:                         .|...:...||            :.|::||
Zfish   266 SEDHVIQY-------------------------VNPAFEKMMGY------------HRGELIGKE 293

  Fly   367 ----------VAQIINKTNGCMEFDEHDVEIF--RRYLTFCGIGIQNAQLFEMSVQEYRRNQILL 419
                      .|.:::..|.|::..:....|:  ||.   .|..||........|.:..:.:..:
Zfish   294 LTELPRSDKNSADLLDTINTCIKKGKEWQGIYFSRRK---SGDSIQQYVKITPVVGQGGKIRHFV 355

  Fly   420 NLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKS 484
            ::.|...:...           :..:|.|.|:|.......:|....|.::..|..:   .|:|.|
Zfish   356 SIKRPYSDNHR-----------QVHKLSKEEKCCGEHSQSECNSLRHKDRRKESVD---VRSISS 406

  Fly   485 ADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVR 549
            ..|........|::.:..:    .:..:..|....::....||.:..|........:.:::....
Zfish   407 HSSDAPSLQNRRYSSMARI----HSMTIEAPITKVINIINAAQESSPVTVAEALDRVLEILRTTE 467

  Fly   550 DHN-QIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKAN-----------GVPFTDSDASIFE 602
            .:: |:.::::...|..::...:.:..:::.|...:.:|:.           .||..|...||.|
Zfish   468 LYSPQLASKEDDPHTNDLVGGLMSDGLRRLSGNEYIFSKSALQNMSQSQLGVPVPLNDIPPSIAE 532

  Fly   603 AFAIFCGLGIHNTQMYE-NACKL-MAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSF 665
            .        ::..:.:| |..:| .|..|..|..|...
Zfish   533 L--------LNEEEQWEFNILELEAATHKRPLSYLGLK--------------------------- 562

  Fly   666 TFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPV-KYHNWRHALNVAQT 729
            .|:.|.:.:          |:.|:        ...|..|:..:..||... .|||..||.:|...
Zfish   563 IFSAFGVCE----------FLNCS--------ESTLRLWLQVIETNYHSSNSYHNSTHAADVLHA 609

  Fly   730 MFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQ 793
            ....|:..:::..:..|:.:..|:|...||:||.|..|:|.....|.|||||. |:.:|.||...
Zfish   610 TAYFLRKERVKASLDQLDEVAALLAATVHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAAL 674

  Fly   794 CVMILNSEGN-NIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFL-----------ELVEN 846
            ...:...:.. |||:.:....:|::.:.:...:|:|::..:|:..|.|:           |...|
Zfish   675 AFQLTVRDSKCNIFKNMERTQFRTLRQAIIDMVLATEMTRHFEHVNKFVNSINKPMSAIEETSSN 739

  Fly   847 GE-FDWQGE-------EKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLN 903
            .| .|.:|:       |.:.|:..|::...||:...:|.|:..:.|..:::|:|.|.|.||.|
Zfish   740 SEGSDCEGQASIRNSPENRLLIKRMLIKCADVANPCRPLELCIEWAGRISEEYFAQTDEEKRQ-- 802

  Fly   904 TQPVAMMDRERKD-ELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAE 963
            ..||.|...:|.. .:||.|:.|||.....::.. .|.|..:..|.|...||.:.|::|.|
Zfish   803 GLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDA-WDAFASLPGLMEHLAENYKYWKNLDE 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	22/174 (13%)
		GAF	431..619	CDD:214500	26/199 (13%)
		PDEase_I	717..950	CDD:278654	69/254 (27%)
pde8b	XP_009293455.1	PDE8	1..47	CDD:285793	9/33 (27%)
		TIM_phosphate_binding	<143..>212	CDD:304361	16/81 (20%)
		PAS_9	260..357	CDD:290162	19/136 (14%)
		PAS	264..357	CDD:238075	19/132 (14%)
		PDEase_I	597..850	CDD:278654	70/255 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010