Protein Alignment Pde6 and pde4d

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_009302145.1
• Gene: pde4d / 566998
• ZFINID: ZDB-GENE-081105-16
• Length: 769
• Species: Danio rerio
• Alignment Length: 670
• Identity: 160/670 - (23%)
• Similarity: 267/670 - (39%)
• Gaps: 171/670 - (25%)

  Fly   408 SVQEYRRN-QILLNLARSIFEEQNNLECLV--------TKIMTEARELLKCERCSVFLVDLDCCE 463
            |::..|.| ..|.|:.:   |..||....:        |....||.:.|..|.    |.:||.|
Zfish   166 SLRTVRNNFAALTNVQQ---ERSNNKRSPMCNPPPITKTSYTEEAYQKLATET----LEELDWC- 222

  Fly   464 ASHLEKIIEKPNQPATR-AIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQ 527
            ...||.:       .|| ::....|.:.|:|.||     ||           ..:||:|.|. .|
Zfish   223 LDQLETL-------QTRHSVSEMASNKFKRMLNR-----EL-----------THLSEMSRSG-NQ 263

  Fly   528 IAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQK----------KVIGVA 582
            :::::::|           ::...|::.             ||...:||          ::.||.
Zfish   264 VSEYISST-----------FLDKQNEVE-------------MPSPQSQKDKEKKKRPMSQISGVK 304

  Fly   583 QLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTE 647
            :|.:.::   .|:|:...|         |:                          .|.::|:..
Zfish   305 KLTHSSS---LTNSNIPRF---------GV--------------------------KTETEDELA 331

  Fly   648 KLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNY 712
            |..:||    ..:.|..|..::|. .:......:..:|.:.:|:..|:||.|....:::::..:|
Zfish   332 KELEDV----NKWGLNVFKVSEFS-GNRPLTVMMYTIFQERDLLKTFKIPLDTFITYLMTLEDHY 391

  Fly   713 R-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 776
            . .|.|||..||.:|.|:...:|.|..:|...||||||..:.|...||:||.|.:|.|...|.|.
Zfish   392 HADVAYHNNIHAADVTQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSE 456

  Fly   777 LAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAF 840
            ||::|. :|.:|:||......:|..|..:|||.|:.:..:|:.|.|...:|:||::.:.......
Zfish   457 LALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADL 521

  Fly   841 LELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE 898
            ..:||..:....|       .::..:|..|:..| |:|...||.::..:....:.:|||.|||.|
Zfish   522 KTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFSQGDRE 585

  Fly   899 KLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFPWITPLYEGTLENRRNWQDL 961
            :.: :...|  |.|:... .:.|.||||||.|..||:....| ..|....:.: |||:.|.|...
Zfish   586 RERGMEISP--MCDKHNA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD-TLEDNREWYQS 646

  Fly   962 A---------------------EKVEMGLTWIDHDTID------KPVEEFAACADEEIKDIEFTV 999
            .                     ||.:..||..:....|      .|.||     |||.::.|..
Zfish   647 TIPQSPSPALDTSSEGRRAAGQEKFQFELTLEEDGESDTEKDSGSPPEE-----DEEEEEEEEN- 705

  Fly  1000 TTLNCNQQSQHGSEDSHTPE 1019
               :|:......::||...|
Zfish   706 ---SCSDSKTLCTQDSECTE 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	39/206 (19%)
		PDEase_I	717..950	CDD:278654	77/242 (32%)
pde4d	XP_009302145.1	PDEase_I	397..634	CDD:306695	77/240 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820