Protein Alignment Pde6 and pde4ca

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_009296827.1
• Gene: pde4ca / 565259
• ZFINID: ZDB-GENE-070912-373
• Length: 742
• Species: Danio rerio
• Alignment Length: 678
• Identity: 160/678 - (23%)
• Similarity: 256/678 - (37%)
• Gaps: 203/678 - (29%)

  Fly   456 LVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEE------KKMRNRFTVLFELGGEYQAANVSR 514
            |.:||.|    ||::         ..:|:..|..|      |:|.||     ||
Zfish   193 LDELDWC----LEQL---------ETLKTRHSVSEMASNKFKRMLNR-----EL----------- 228

  Fly   515 PSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKK-- 577
            ..:||.|.|. .|:::::::|                 .:..:.::|    |:..|....:||
Zfish   229 TQLSETSKSG-NQVSEYISST-----------------FLEKQHDMD----IMSTPSKEKEKKKR 271

  Fly   578 ----VIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYH 638
                :.||.:..:.:|..|      |....|.:
Zfish   272 PMSQISGVKKPTHSSNIAP------SSIPRFGV-------------------------------- 298

  Fly   639 ATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCR----AVLRMFMQCNLVSQFQIPYD 699
            :|..:|...|       |.|.::.:....  |::.:....|    |:...|.:.:|:..|:||.|
Zfish   299 STNREDLLAK-------ELEDFDRWGVDM--FKISECSGNRPLTVAMYTTFQERDLLKSFKIPVD 354

  Fly   700 VLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHR 763
            ....::.::.:||| .|.|||..||.:|.|:...:|.|..:|...||||||..:.|...||:||.
Zfish   355 TFINYMTALEENYRSDVAYHNSIHAADVVQSTHVLLSTPALEAVFTDLEILAAMFASAIHDVDHP 419

  Fly   764 GTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILS 827
            |.:|.|...|.|.||::|. :|.:|:||......:|..|..:|||.|:.:..:|:.|.|...:|:
Zfish   420 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDMVLA 484

  Fly   828 TDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAKPWEVQHKVAK 885
            ||::.:.........:||..:....|       .::..:|..|:..| |:|...||.|:..:...
Zfish   485 TDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCA-DLSNPTKPLELYRQWTD 548

  Fly   886 LVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFPWITPLY 948
            .:..|||.|||.|:.: :...|  |.|:... .:.|.||||||.|..||:....| ..|....:.
Zfish   549 RIMVEFFTQGDRERDKGMEISP--MCDKHNA-SIEKSQVGFIDYIVHPLWETWADLVHPDAQEIL 610

  Fly   949 EGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSE 1013
            : |||:.|.|                                               .||.....
Zfish   611 D-TLEDNREW-----------------------------------------------YQSMIPHS 627

  Fly  1014 DSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKL-------LESHVSEDM 1071
            .:.|||     .:.::...||:|..:.|.          |.|.:..|.|       :||.|.||:
Zfish   628 PTSTPE-----DKSAVMGMGAMGGGIASA----------GDKFQFELTLEEEGESDVESPVDEDL 677

  Fly  1072 D----DKSPTSPSQPQASGSMGRMSASS 1095
            .    |.|.|.|...|.|.:...:||.|
Zfish   678 TSSTRDSSRTDPQGKQTSPAARLLSARS 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	32/174 (18%)
		PDEase_I	717..950	CDD:278654	78/242 (32%)
pde4ca	XP_009296827.1	PDEase_I	373..610	CDD:306695	78/240 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820