Protein Alignment Pde6 and pde1a

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_005167982.1
• Gene: pde1a / 564465
• ZFINID: ZDB-GENE-090831-2
• Length: 611
• Species: Danio rerio
• Alignment Length: 646
• Identity: 162/646 - (25%)
• Similarity: 270/646 - (41%)
• Gaps: 140/646 - (21%)

  Fly   542 CDVIE--WVR---------------------DHNQIRAED---EIDSTQAILCMPIMNAQKKVIG 580
            ||..|  |:|                     |..::...|   .|:...::|....::..::::.
Zfish    20 CDQTEKMWIRLKGMQKYKNTSQRLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLD 84

  Fly   581 VAQLIN--KANGVPFTDSD--ASIFE-------------------AFAIFCGLGIHNTQMYENAC 622
            ....::  :|:.||....|  ||.|.                   ..|:..|:.:.  :||....
Zfish    85 TEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVE--RMYRRTS 147

  Fly   623 KLMAKQKVALECLSYH---ATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRM 684
            .:..        |:|.   .||.:| .:|.:.||....|:.:.::..|..:||:
Zfish   148 NMAG--------LTYPPSVITALKD-VDKWSFDVFKLQEASSDHALKFLVYELL----------- 192

  Fly   685 FMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKMERFMTDL 746
             .:.:|:|:|:||...|..:|.::...|...:  |||..||.:|.||. :.||.||.| .::|:|
Zfish   193 -TRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVM-HWLTEL 255

  Fly   747 EILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALS 810
            |||.::.|...||.:|.||.|.|..:|.|.:||||. .|.:|:||......::..:..||...||
Zfish   256 EILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLS 320

  Fly   811 PEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAK 875
            .:|:|.:...|...::|||::.:|::    ::.:.|.....:|.:|...| .:|:.|.|:|..||
Zfish   321 KDDWRELRTLVIEMVMSTDMSCHFQQ----IKTMRNSLQQPEGIDKAKAL-SLMLHAADISHPAK 380

  Fly   876 PWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD 939
            .|::.::..:.:.:|||.|||.| :|.|...|  :.|| :...:.:.|:||||.|..|.:.||.|
Zfish   381 GWKLHYRWTQALMEEFFRQGDKEAELGLPFSP--LCDR-KATMIAQSQIGFIDFIVEPTFSVLVD 442

  Fly   940 TF-PWITPLYE-------------------GTLENRRNWQDLAEKVEMG------LTWIDHDTID 978
            |. ..|:||.|                   ..:|:.:...|.....|.|      |..||...:.
Zfish   443 TTEKIISPLIEEAVKSGGVRRSSLTGRGSAAVVESVQRHSDRGSNDECGGSTDYSLCGIDQKHVR 507

  Fly   979 KPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKL 1043
            ..:.|......|..|  |.:|..| .|:|.:..|:....|          |:.|         :|
Zfish   508 HLLSEIIQNNKERWK--ELSVQEL-ANKQHERMSDLQEEP----------MRST---------QL 550

  Fly  1044 SKTLYNSMDGSKPKTSLKLLES-HVSEDMDDKSPTSPSQPQASGSMGRMSASSSTSSAGGQ 1103
            :.:..|....||....|...:| |.|:|..|:|..||:  :.:|.......||.|....|:
Zfish   551 TLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPT--EGAGDASPEEHSSETLPWNGK 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	19/125 (15%)
		PDEase_I	717..950	CDD:278654	85/255 (33%)
pde1a	XP_005167982.1	PDEase_I_N	85..141	CDD:285672	9/57 (16%)
		PDEase_I	226..442	CDD:278654	79/224 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920