DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde11a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_689838.4	Gene:	pde11a / 561338	ZFINID:	ZDB-GENE-070912-207	Length:	894	Species:	Danio rerio

Alignment Length:	887	Identity:	368/887 - (41%)
Similarity:	515/887 - (58%)	Gaps:	111/887 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 VDEVARLFEE------KPEAFEKWLTE--RAPPEA---------------LSRLQEFIENRKPHK 184
            :||...|.|:      |....|||:..  :.|.:|               |.|.....|.||...
Zfish    15 LDEHPELLEDYLNRKGKASMVEKWMKSHPKTPEKAASACAKDSWASRGDGLQRRASQKELRKTFA 79

  Fly   185 RPSV-----TSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLM----------------- 227
            |...     |.|......|..|....:. |:|.. .|||||....|::
Zfish    80 RSKAINANRTYDEHVNSRAQEPLTSMRR-RALLR-KASSLPPTTAHILSALLESRVNIPQYPSTA 142

  Fly   228 --------DLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVA 284
                    :.:|.|.|:||::|::|:||:..|.:||||.|.::..|||.||||.:|....|.||:
Zfish   143 VDYKYYLKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGPTNKKTLVS 207

  Fly   285 KLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKT 349
            |.|||...|.:..::  ::::|:.:|:|.||.|.||:..:.:||.:||:|.||:.|||..|||||
Zfish   208 KFFDVHAGTTVLPSL--SNSDEVQVPWGKGIIGYVAEHGETVNIPDAYQDHRFSDEIDKLTGYKT 270

  Fly   350 NAILCMPICNYEGDIIGVAQIINKT-NGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYR 413
            .::|||||.|.:|::|||||.|||: ||.: |.:.|.::.:.||.||||.|.|||||..|.:||.
Zfish   271 KSLLCMPIHNSDGEVIGVAQAINKSPNGAL-FTQDDEKVLQMYLPFCGIAISNAQLFAASRKEYD 334

  Fly   414 RNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPA 478
            |::.||.:...:||||.:||.:|.|||..|:.|||||||||.|::           .||.|
Zfish   335 RSRALLEVVNDLFEEQTDLEKIVRKIMHRAQTLLKCERCSVQLLE-----------DIESP---- 384

  Fly   479 TRAIKSADSFE------EKKMRNRFTVLFELGGEYQAANVSRPSVSE--LSSSTLAQIAQFVATT 535
              .:|...|||      ...|.|.|           ..::.:.|.|:  :::|    ||:.||:|
Zfish   385 --VVKFTKSFELLSPKCSADMENSF-----------KDSMDKSSYSDWLINNS----IAELVAST 432

  Fly   536 GQTVNICDVIEWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVIGVAQLINKANGVPFTD 595
            |..|||.|.      :...|.:.|.|.     .:::||:||.|:..::|||||::|:.:|.||.|
Zfish   433 GLPVNISDA------YQDPRFDAEADQFSGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDD 491

  Fly   596 SDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESY 660
            :|..:||||.|||||||:||.||:...|..|||.|||:.||||||.|:.:.:|.....|......
Zfish   492 ADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKTEVDKFKAANIPLVCEL 556

  Fly   661 NLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALN 725
            .:...:|.||.|..|....|.|||||:..:|.:|:|.|:.||||:|:||||||.|.|||||||.|
Zfish   557 GIDKLSFDDFSLDVDAMVTAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFN 621

  Fly   726 VAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHH 789
            |.|.||:||.|...:..:|::|.|.|:|.|:||||||||||||||.||.|.|::|| |::|:|||
Zfish   622 VCQCMFSMLTTAGFQETLTEMETLALIVGCICHDLDHRGTNNAFQAKTGSALSLLYGTSATLEHH 686

  Fly   790 HFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGE 854
            ||:..||||.|||:|||..||..:|..:|:.::.:||:|||.:||:.||:|.|||..||::|..:
Zfish   687 HFNHAVMILQSEGHNIFSNLSSHEYGELMQLLKQSILATDLTLYFQNRNSFFELVNKGEYNWNVK 751

  Fly   855 EKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELP 919
            |.:::...|:|||||:.|:.||||:.||||:||..|||:|||.|:.:|...|.|:.||.||||||
Zfish   752 EHREMCRSMLMTACDLGAVTKPWEISHKVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELP 816

  Fly   920 KMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDL 961
            .:|:.:||.||.|||.......|.:.|:.:....||..|::|
Zfish   817 GLQLEWIDGICAPLYETFAKLNPKLQPMMDLIKANRAKWEEL 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	76/159 (48%)
		GAF	431..619	CDD:214500	73/200 (37%)
		PDEase_I	717..950	CDD:278654	124/233 (53%)
pde11a	XP_689838.4	GAF	170..330	CDD:214500	77/162 (48%)
		GAF	352..518	CDD:214500	74/203 (36%)
		PDEase_I	613..849	CDD:278654	124/235 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56763
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		mtm6603
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.830