DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde6b

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_685002.1	Gene:	pde6b / 559332	ZFINID:	ZDB-GENE-090421-2	Length:	854	Species:	Danio rerio

Alignment Length:	924	Identity:	288/924 - (31%)
Similarity:	460/924 - (49%)	Gaps:	134/924 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSP 208
            ::|.:..:..|:..:.:..::..|.|::.:....|::       |..|.|::
Zfish     6 EDVEKFLDGNPDFTKTYFDKKLKPGAVASIMRVPESK-------VDMDSFKE------------- 50

  Fly   209 RSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLA 273
                             ::.::||.:|.:||.|:...::::.:..|||..:..|.||||.|||:.
Zfish    51 -----------------IVSVEEGAIFYDLITDMQENVNMEKVIFKILKRISALIHADRCSLFMY 98

  Fly   274 KGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFN 338
            :.......|..:||:|.:.:.|.|.|. |...||:.|..|||.|.|||||:.:|:|:..:|:.|:
Zfish    99 RQRNGIAELATRLFNVNKDSELDDCVV-APDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQDSHFS 162

  Fly   339 CEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQ 403
            ..:|..|.|.|:.:|..||.|.: |::.|...:|||.| ..|.:.|:::|.:||.   :|..|.:
Zfish   163 TFVDELTEYTTHNLLAAPIMNGK-DVVAVIMAVNKTTG-PHFTDEDMDLFLKYLK---VGSLNLK 222

  Fly   404 LFEMSVQ---EYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEAS 465
            :|.:|..   |.|:.|:||..|..:|||..::|....|.:...|..|.|:|.||.|:|:.
Zfish   223 IFHLSYLHNCETRKGQLLLWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMT----- 282

  Fly   466 HLEK------IIEKPNQPATRAIKSADSFEEKKMRNRFTVLFE------LGGEYQAANVSRPSVS 518
             .||      .:....||......:.|..|         ::|.      |.|:.....:..|:..
Zfish   283 -KEKEFFDIWPVLMGEQPPYSGPVTPDGRE---------IIFYKVIDYILHGKEDIKVIPNPTAD 337

  Fly   519 E--LSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDST-QAILCMPIMNAQKKVIG 580
            .  |:|.    :..:||.:|...||.:.........|..|.|:...| :.:|.:||:|.:::::|
Zfish   338 HWALASG----LPTYVAESGFICNIMNAASEEMFKFQTEALDDSGWTIKNVLSLPIVNKKEEIVG 398

  Fly   581 VAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQ 645
            ||...|:.:|.||.:.|..:.||...|.|....||..|:...||..::.:|.:.:.||.....|:
Zfish   399 VATFYNRKDGKPFDEHDEQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQDMVLYHVKCRDDE 463

  Fly   646 TEKLTQDVIAEAE--------------------------SYNLYSFTFTDFELVDDDTCRAVLRM 684
                .||::...|                          .:.:|:|.|:||:..:.......::|
Zfish   464 ----IQDILKTREYFDREPRDCEEEELLEILKKELPGPKKFEIYAFHFSDFDCTELQLVMCGIQM 524

  Fly   685 FMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEIL 749
            :.:..:|.:||:|.:||.|::.||.|.||.:.||||||..||.||||.:|.|||::::.||||::
Zfish   525 YYEVGVVKKFQVPQEVLVRFMYSVSKGYRRITYHNWRHGFNVGQTMFTLLTTGKLKQYYTDLEVM 589

  Fly   750 GLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDY 814
            .::.|...||:|||||||.:|.|:::|||.|:.:|.:|.||.:....:|..|..||||.|:....
Zfish   590 AMITAGFLHDIDHRGTNNLYQVKSQNPLAKLHGSSILERHHLEFGKFLLGEESLNIFQNLNRRQT 654

  Fly   815 RSVMKTVESAILSTDLAMYFKKRNAFLELVENGE--------FDWQGEE--KKDLLCGMMMTACD 869
            ..|...::.||::||||:|||||..|.::|:..|        .|:...|  :|:::..|||||||
Zfish   655 EHVFHLIDIAIIATDLALYFKKRTMFQKIVDLSETYEERKKWIDFMSLETTRKEIVMAMMMTACD 719

  Fly   870 VSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLY 934
            :|||.||||||.|||..||.||::|||||:..|..||:.||||.:..||||:|.||||.:|..:|
Zfish   720 LSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPKLQCGFIDFVCTFVY 784

  Fly   935 RVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTV 999
            :......|.|.|:::|.|.||.:|::..|:.|..|         |.:||......|..     ..
Zfish   785 KEFSRFHPEIKPMFDGILNNRMHWKERQEEYEAKL---------KAMEEAVKARQEAA-----AK 835

  Fly  1000 TTLNCNQQSQHGSE 1013
            ...|.|.....||:
Zfish   836 NAANSNSTGGSGSK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	56/158 (35%)
		GAF	431..619	CDD:214500	49/202 (24%)
		PDEase_I	717..950	CDD:278654	114/242 (47%)
pde6b	XP_685002.1	GAF	72..210	CDD:214500	51/140 (36%)
		GAF	253..440	CDD:214500	50/205 (24%)
		PDEase_I	557..801	CDD:278654	114/243 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930