DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and pde4bb

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_009296519.1	Gene:	pde4bb / 555599	ZFINID:	ZDB-GENE-070912-454	Length:	707	Species:	Danio rerio

Alignment Length:	574	Identity:	145/574 - (25%)
Similarity:	239/574 - (41%)	Gaps:	122/574 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 QILLNL--ARSIFEEQNNLEC------------LVTK--IMTEARELLKCERCSVFLVDLDCCEA 464
            |:|.:|  .|:.|....|:.|            .|||  :..|:.:.|..|.    :.:||.| .
Zfish   166 QVLASLRTVRNNFSILTNVSCPSSKRSPISSHGPVTKANLSDESYQKLALET----MEELDWC-L 225

  Fly   465 SHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIA 529
            ..||.|      ...|::....|.:.|:|.||     ||           ..:||:|.|. .|::
Zfish   226 DQLETI------QTYRSVSDMASNKFKRMLNR-----EL-----------THLSEMSRSG-NQVS 267

  Fly   530 QFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFT 594
            :|::.|           ::...|::    ||.     |..|....:||  ...||:.:.:||.
Zfish   268 EFISNT-----------FLDKQNEL----EIP-----LSTPKSRERKK--RQQQLMTQISGVR-- 308

  Fly   595 DSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAES 659
                                        |:......:..|.:.......|..:.|::|:    |.
Zfish   309 ----------------------------KVTHGSGPSSSCSTTRFGVKTDSEDMLSKDL----ED 341

  Fly   660 YNLYSFTFTDFELVDDDTCR----AVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKYHN 719
            .|.:....  |::.:....|    .:..:|.:.:|:..|:||.|....:::::..:|. .|.|||
Zfish   342 INKWGLNI--FKVAEHSHHRPLACIMYAIFQERDLMKTFKIPVDTFVTYMMTLEDHYHADVAYHN 404

  Fly   720 WRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-T 783
            ..||.:|||:...:|.|..::...||||||..|.|...||:||.|.:|.|...|.|.||::|. .
Zfish   405 SLHAADVAQSTHILLSTPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 469

  Fly   784 STMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGE 848
            |.:|:||......:|..|..::||.||.::.:::.|.|...:|:||::.:.........:||..:
Zfish   470 SVLENHHLAVGFKLLQGENCDLFQNLSKKERQTLRKMVIHMVLATDMSKHMSLLADLKTMVETKK 534

  Fly   849 FDWQG-------EEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQ 905
            ....|       .::..:|..|:..| |:|...||.::..:....:..|||.|||.|:.: :...
Zfish   535 VTSSGVLLLDNYTDRIQVLRNMVHCA-DLSNPTKPLDLYKQWTDRIMQEFFHQGDRERERGMEIS 598

  Fly   906 PVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFPWITPLYEGTLENRRNW 958
            |  |.|:... .:.|.||||||.|..||:....| ..|....:.: |||..|||
Zfish   599 P--MCDKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD-TLEENRNW 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	40/201 (20%)
		PDEase_I	717..950	CDD:278654	77/242 (32%)
pde4bb	XP_009296519.1	PDEase_I	402..643	CDD:278654	78/245 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820