DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde6 and PDE6B

DIOPT Version :9

Sequence 1:NP_001262566.1 Gene:Pde6 / 41760 FlyBaseID:FBgn0038237 Length:1124 Species:Drosophila melanogaster
Sequence 2:XP_011511775.1 Gene:PDE6B / 5158 HGNCID:8786 Length:941 Species:Homo sapiens


Alignment Length:950 Identity:292/950 - (30%)
Similarity:480/950 - (50%) Gaps:136/950 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 SSETKLMTPTGSSSSPSQ------SPS-------QTQA-SIQTQTS----------QQDRLAKAS 135
            |.:..::.|.|...:||.      .||       :.|| ..|.:.|          :|.||...:
Human     7 SGKASVLFPVGQRVTPSSVVPPCVRPSFVACLHCRCQAGDTQDRPSMGFLGVHACLEQQRLQGQA 71

  Fly   136 TTASQQDVDEVARLF-EEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAA 199
            .|.|..  :|.||.| ::.|:...::..::..||.::..   .|:..|                 
Human    72 ATMSLS--EEQARSFLDQNPDFARQYFGKKLSPENVAAA---CEDGCP----------------- 114

  Fly   200 SPTVQQKSPRSLSNSSASSLPEC--RRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLL 262
                                |:|  .|.|..::|....:||::|:...::::.:..|:|..:..|
Human   115 --------------------PDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTL 159

  Fly   263 THADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMIN 327
            ..|||.|||:.:.......|..:||.|...:.|:|.:....: ||:.|..||:.|.|||||:|:|
Human   160 LQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDS-EIVFPLDIGVVGHVAQTKKMVN 223

  Fly   328 IKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYL 392
            :::..:...|:...|..|.|||..:|..||.|.: |::.|...:||.||.. |...|.::|.:||
Human   224 VEDVAECPHFSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPF-FTSEDEDVFLKYL 286

  Fly   393 TFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLV 457
            .|..:.::...|..:...|.||.|:||..|..:|||..::|....|.....|..|.|||.||.|:
Human   287 NFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLL 351

  Fly   458 DLDCCEASHLEK-------IIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRP 515
            |:.      .||       ::...:||.: ..::.|..|....:   .:.:.|.|:.:...:..|
Human   352 DMT------KEKEFFDVWSVLMGESQPYS-GPRTPDGREIVFYK---VIDYVLHGKEEIKVIPTP 406

  Fly   516 SVSE--LSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDST----QAILCMPIMNA 574
            |...  |:|.    :..:||.:|   .||:::....|......|..:|.:    :.:|.|||:|.
Human   407 SADHWALASG----LPSYVAESG---FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNK 464

  Fly   575 QKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYH- 638
            :::::|||...|:.:|.||.:.|..:.|:...|.|..:.||..|:...||..::.:|.:.:.|| 
Human   465 KEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHV 529

  Fly   639 ---------------------ATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVL 682
                                 |...:|:..::.::.:....::::|.|.|:|.|..:.|..:..:
Human   530 KCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGI 594

  Fly   683 RMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLE 747
            :|:.:..:|.:||||.:||.|::.|:.|.||.:.||||||..|||||||.:|.|||::.:.||||
Human   595 QMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLE 659

  Fly   748 ILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPE 812
            ...::.|.||||:|||||||.:|.|:::|||.|:.:|.:|.||.:....:|:.|..||:|.|:..
Human   660 AFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRR 724

  Fly   813 DYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEE-----------KKDLLCGMMMT 866
            .:..|:..::.||::||||:|||||..|.::|:..: ::|.::           :|:::..||||
Human   725 QHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVEYLSLETTRKEIVMAMMMT 788

  Fly   867 ACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICL 931
            |||:|||.||||||.|||.|||.||::|||||:..|:.||:.||||.:..||||:||||||.:|.
Human   789 ACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 853

  Fly   932 PLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTW 971
            .:|:........|.|:::....||:.|:.||:.....|.|
Human   854 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADDRHRNLQW 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde6NP_001262566.1 GAF 247..406 CDD:214500 51/158 (32%)
GAF 431..619 CDD:214500 49/200 (25%)
PDEase_I 717..950 CDD:278654 115/243 (47%)
PDE6BXP_011511775.1 GAF 144..303 CDD:214500 51/161 (32%)
GAF 325..512 CDD:214500 50/203 (25%)
PDEase_I 629..874 CDD:278654 115/245 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG56437
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11347
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.930

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