Protein Alignment Pde6 and PDE9A

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_002597.1
• Gene: PDE9A / 5152
• HGNCID: 8795
• Length: 593
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 168/682 - (24%)
• Similarity: 273/682 - (40%)
• Gaps: 174/682 - (25%)

  Fly   412 YRRNQILLN----LARSIFEEQNN------LECLVTKIMTEAR-ELLKCERCSVFLVDLDCCEAS 465
            ||...|.|:    :.:.||.:..|      |.|:.|.:..... .||..:..   :|.:|....:
Human     8 YRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDA---MVSIDPTMPA 69

  Fly   466 HLEKIIEKPNQPATRAIK---------SADSFEEKKMRNRFTV---------LFELG-------- 504
            :.|:...|....|.:.:.         |.....|:.:|:|..|         .||.|
Human    70 NSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPRE 134

  Fly   505 --GEYQAANVSRPSVSELSSSTLAQIA-QFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAI 566
              |.||......|...||..|.|||:| ||    .:...|          |:::|  |:.:..|:
Human   135 PQGCYQEGQRIPPEREELIQSVLAQVAEQF----SRAFKI----------NELKA--EVANHLAV 183

  Fly   567 LCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVA 631
            |       :|:|    :|.                       ||.:...:..::..|.|.::..|
Human   184 L-------EKRV----ELE-----------------------GLKVVEIEKCKSDIKKMREELAA 214

  Fly   632 ----LECLSYHATASQDQTEKLT--QDVIAEAESYNLYSFTFTDFELVDDDTCRAVLR------- 683
                ..|...::..  |..:|||  :||    .:|..|        |:..:|..|:.:
Human   215 RSSRTNCPCKYSFL--DNHKKLTPRRDV----PTYPKY--------LLSPETIEALRKPTFDVWL 265

  Fly   684 ------------MFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKT 736
                        |:....||..|.|....|.||:..|..|||...:||:||...|||.|::|:..
Human   266 WEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 330

  Fly   737 GKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNS 800
            ..::...:..:||.|:.|.:||||||.|.||.:|....:.||:.|. .|.:|:||......||..
Human   331 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAE 395

  Fly   801 EGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMM 865
            ...|||..:.|:.::.:.:.:.:.||:||:|.:.:..::|.|.:||  ||:..||...||..:::
Human   396 PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKMILI 458

  Fly   866 TACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVA-MMDRERKDELPK--MQVGFID 927
            ..||:|...:|.||.......:.:|:|.|.|.||.:  ..||| .|||   |::.|  .|:|||.
Human   459 KCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDR---DKVTKATAQIGFIK 518

  Fly   928 VICLPLYRVLCDTFPWI-----TPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAAC 987
            .:.:|::..:...||.:     .||:    |:|..:::|..             ||..::|....
Human   519 FVLIPMFETVTKLFPMVEEIMLQPLW----ESRDRYEELKR-------------IDDAMKELQKK 566

  Fly   988 ADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPE 1019
            .|.         .|....::|:..|.|....|
Human   567 TDS---------LTSGATEKSRERSRDVKNSE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	43/223 (19%)
		PDEase_I	717..950	CDD:459723	80/241 (33%)
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..141		10/53 (19%)
		PDEase_I	311..539	CDD:459723	78/234 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593		6/35 (17%)