Protein Alignment Pde6 and PDE8A

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_002596.1
• Gene: PDE8A / 5151
• HGNCID: 8793
• Length: 829
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 172/815 - (21%)
• Similarity: 306/815 - (37%)
• Gaps: 213/815 - (26%)

  Fly   238 LIRDVAN--ELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVT 300
            :|.|..|  :||.:.||..|           |.|                  .:::.|.:...|.
Human   128 IIIDHRNPRQLDAEALCRSI-----------RSS------------------KLSENTVIVGVVR 163

  Fly   301 RASAEEI-IIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDI 364
            |...||: ::|| |. ||...:..:..||...|.:.     :.|:.| :..:.|.:..||
Human   164 RVDREELSVMPF-IS-AGFTRRYVENPNIMACYNEL-----LQLEFG-EVRSQLKLRACN----- 215

  Fly   365 IGVAQIINKTNGCMEFDEHDVEIFRRYLTFCG------IGIQNAQLF-----EMSVQEYRRNQI- 417
             .|...:..:...:|....|     |::.:..      :|.|:.:|.     |:.:.|.:.:.:
Human   216 -SVFTALENSEDAIEITSED-----RFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLD 274

  Fly   418 LLNLARSIFEE---------------QNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHL 467
            .:|....|.:|               |.|::  :..::.:..::    |..|.::.: |...:..
Human   275 TINSCIRIGKEWQGIYYAKKKNGDNIQQNVK--IIPVIGQGGKI----RHYVSIIRV-CNGNNKA 332

  Fly   468 EKIIE-------KPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTL 525
            |||.|       ..||......:...|.:.|.:.:|.|   |:..:.:.::::|     :.|.|:
Human   333 EKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRAT---EVSSQRRHSSMAR-----IHSMTI 389

  Fly   526 AQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGV---AQLINK 587
            .      |...:.:||                  |::.|....||:..|..:|:.:   .:|.:.
Human   390 E------APITKVINI------------------INAAQESSPMPVTEALDRVLEILRTTELYSP 430

  Fly   588 ANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQD 652
            ..|....|..|:     .:..||      |.:...:|...:.|          .|...|:.::.:
Human   431 QFGAKDDDPHAN-----DLVGGL------MSDGLRRLSGNEYV----------LSTKNTQMVSSN 474

  Fly   653 VIA---------------EAESYNLYSFTFTDFELVDDDTCRAV----LRMFMQCNLVSQFQIPY 698
            :|.               |.|.|    :.|..|||......|.:    |:||.:..:........
Human   475 IITPISLDDVPPRIARAMENEEY----WDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSE 535

  Fly   699 DVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDH 762
            ..|..|:..:..||.... |||..|:.:|.......|...:::..:..::.:..|:|...||:||
Human   536 STLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 600

  Fly   763 RGTNNAFQTKTESPLAILYT-TSTMEHHHF----------DQCVMILNSEGNNIFQALSPEDYRS 816
            .|..|:|.....|.|||||. |:.:|.||.          |:|         |||:.:...|||:
Human   601 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKC---------NIFKNMERNDYRT 656

  Fly   817 VMKTVESAILSTDLAMYFKKRNAFLE--------LVENGEFDWQGE---------EKKDLLCGMM 864
            :.:.:...:|:|::..:|:..|.|:.        |.||||.|...|         |.:.|:..|:
Human   657 LRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKD-ELPKMQVGFIDV 928
            :...|||...:|.:...:.|..:::|:|.|.|.||.|  ..||.|...:|.. .:||.|:.|||.
Human   722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQ--GLPVVMPVFDRNTCSIPKSQISFIDY 784

  Fly   929 ICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAE 963
            ....::.. .|.|..:..|.:....|.:.|:.|.|
Human   785 FITDMFDA-WDAFVDLPDLMQHLDNNFKYWKGLDE 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	31/170 (18%)
		GAF	431..619	CDD:214500	34/197 (17%)
		PDEase_I	717..950	CDD:459723	73/261 (28%)
PDE8A	NP_002596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..46
		RpfG	73..>169	CDD:442663	13/69 (19%)
		PAS	219..>324	CDD:441804	15/115 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..360		2/18 (11%)
		Involved in RAF1-binding. /evidence=ECO:0000269|PubMed:23509299	454..461		1/6 (17%)
		PDEase_I	555..806	CDD:459723	73/262 (28%)