DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and PDE7A

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001229247.1	Gene:	PDE7A / 5150	HGNCID:	8791	Length:	482	Species:	Homo sapiens

Alignment Length:	398	Identity:	107/398 - (26%)
Similarity:	178/398 - (44%)	Gaps:	57/398 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   592 PFTDSDASIFEAFAIFCGLGIHNTQMYE------NACKLMAKQKVALECLSYHATASQDQTEKLT 650
            |:.|        |.||     |:....|      |..:|::.|:.......:..||..:....|.
Human    86 PYID--------FRIF-----HSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILD 137

  Fly   651 QDVIAEA----ESYNLYSFTFTDFELVDDDTCRAVL--RMFMQCNLVSQFQIPYDVLCRWVLSVR 709
            .|...:|    |....::|....|:.:.:......|  .:|....|:..|.:....|.|:::.::
Human   138 DDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQ 202

  Fly   710 KNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKT 773
            ::|.... |||..||.:|.|.|...||..|:...:|..:||..|:|...|||||.|.|..|..||
Human   203 EDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267

  Fly   774 ESPLAILY-TTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKT-VESAILSTDLAMYFKK 836
            ...||.|| .||.:|:||:...|.:|...|  :|..| |.:.|..|:| :.:.||:||::    :
Human   268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHL-PLESRQQMETQIGALILATDIS----R 325

  Fly   837 RNAFLEL----VENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDL 897
            :|.:|.|    ::.|:...:....:.|:..|.:...|:....:.||:..:.::.|.:|||.|||:
Human   326 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDI 390

  Fly   898 E-KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWI----TPLYEGTLE---- 953
            | |..|...|  :.|| ..:.:..:|:||:..:..||:.      .|.    |.|.:..|.
Human   391 EKKYHLGVSP--LCDR-HTESIANIQIGFMTYLVEPLFT------EWARFSNTRLSQTMLGHVGL 446

  Fly   954 NRRNWQDL 961
            |:.:|:.|
Human   447 NKASWKGL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	6/26 (23%)
		PDEase_I	717..950	CDD:278654	78/243 (32%)
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	79/248 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820