DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and PDE6C

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_006195.3	Gene:	PDE6C / 5146	HGNCID:	8787	Length:	858	Species:	Homo sapiens

Alignment Length:	884	Identity:	294/884 - (33%)
Similarity:	458/884 - (51%)	Gaps:	84/884 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 AFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLP 220
            |.||:|.|. |..|    :|:.:.:   .|..|..::|:     :..|..:|..|.|
Human     8 AVEKYLEEN-PQFA----KEYFDRK---LRVEVLGEIFK-----NSQVPVQSSMSFS-------- 51

  Fly   221 ECRRHLMDLDEGELFMELIRDVANELDI-DVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVA 284
                .|..::|..|.:||:..|..|... :...|:.|..:..|..|||.|:||.:.......:.:
Human    52 ----ELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVAS 112

  Fly   285 KLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKT 349
            :|.|||..:..:|.:. ...:|::.|..|||.|..|.||:..|:.:..|::.|:..:|.:|||.|
Human   113 RLLDVTPTSKFEDNLV-GPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVT 176

  Fly   350 NAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRR 414
            ..:|..||. ...:::.|...:||.| ..||.:.|.|:|.:||.|..|.::......|...|.||
Human   177 KNLLATPIV-VGKEVLAVIMAVNKVN-ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRR 239

  Fly   415 NQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPAT 479
            :|||:..|..:|||..::|....|.:...|..|.|||.|:.|:|:...:..:.|..|:.......
Human   240 SQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304

  Fly   480 RAIKSADSFEEKKMRNRFTVL-FELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICD 543
            :..|:.|..|.    |.:.:: :.|.|:.:...:..|.....  :.::.:..:||..|   .||:
Human   305 KGPKTPDGREV----NFYKIIDYILHGKEEIKVIPTPPADHW--TLISGLPTYVAENG---FICN 360

  Fly   544 VIEWVRDHNQIRAEDEIDST----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAF 604
            ::....|......:..:|.|    :.:|.:||:|.::.::|||...|:.:|.||.:.|..|.|..
Human   361 MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETL 425

  Fly   605 AIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQ-------TEKLTQDVIAEAE---- 658
            ..|.|..:.||..|:...||..::.:|.|.|.....|:.::       .|||..|||.:.|
Human   426 TQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQL 490

  Fly   659 ------------SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKN 711
                        |..||.|.|:||.|.:....:..:|:|.:.|:|.:|::|.:||.||:.:|||.
Human   491 VAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKG 555

  Fly   712 YRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 776
            ||.|.||||||..||.||||.:|.||:::::.||||...:|.|..|||:|||||||.:|.|:.||
Human   556 YRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSP 620

  Fly   777 LAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFL 841
            ||.|:.:|.:|.||.:....:|..|..||||.|:...:.:|:...|.||::||||:|||||..|.
Human   621 LARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQ 685

  Fly   842 ELVENGEFDWQGEE-----------KKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQG 895
            ::|:..| ..|.||           ||:::..|||||||:|||.||||||.:||.:||:||::||
Human   686 KIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQG 749

  Fly   896 DLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQD 960
            |||:..|..||:.||||.::|||||:||||||.:|..:|:........|||:..|...||..|:.
Human   750 DLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKS 814

  Fly   961 LAEKVEMGLTWIDHDT------IDKPVEEFAACADEEIK 993
            ||::.:..:..|:.:.      .:|..|:.....|::.|
Human   815 LADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	47/159 (30%)
		GAF	431..619	CDD:214500	45/192 (23%)
		PDEase_I	717..950	CDD:278654	120/243 (49%)
PDE6C	NP_006195.3	GAF	80..231	CDD:214500	47/153 (31%)
		GAF	256..443	CDD:214500	46/195 (24%)
		PDEase_I	561..806	CDD:278654	121/245 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..858		4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930