Protein Alignment Pde6 and PDE6A

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_000431.2
• Gene: PDE6A / 5145
• HGNCID: 8785
• Length: 860
• Species: Homo sapiens
• Alignment Length: 834
• Identity: 263/834 - (31%)
• Similarity: 429/834 - (51%)
• Gaps: 93/834 - (11%)

  Fly   183 HKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELD 247
            |.|..:.|||.....||.......||.|                  ::|.|:..:|:||....|.
Human    27 HYRAKLISDLLGAKEAAVDFSNYHSPSS------------------MEESEIIFDLLRDFQENLQ 73

  Fly   248 IDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFG 312
            .:.....::..:..|..|||.|||:.:.......|..:||:|.:...|:|.:.... :||:.|..
Human    74 TEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPD-QEIVFPLD 137

  Fly   313 IGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGC 377
            :||.|.||.:|::.|:....:|..|...:|:.|.|||..||..||.|.: |::.:...:||.:|
Human   138 MGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNGK-DVVAIIMAVNKVDG- 200

  Fly   378 MEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTE 442
            ..|.:.|.||..:||.|..:.::...|..:...|.||.||||.....:|||..::|....|.:..
Human   201 SHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYT 265

  Fly   443 ARELLKCERCSVFLVDLDCCEASHLEKIIE-------------KPNQPATRAIKSADSFEEKKMR 494
            .|..|.|:|.||.|:|:     :..::..:             .|..|..|.|
Human   266 VRAFLNCDRYSVGLLDM-----TKQKEFFDVWPVLMGEVPPYSGPRTPDGREI------------ 313

  Fly   495 NRFTVL-FELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAED 558
            |.:.|: :.|.|:.....:..|.....  :.::.:..:||..|.   ||:::....:......::
Human   314 NFYKVIDYILHGKEDIKVIPNPPPDHW--ALVSGLPAYVAQNGL---ICNIMNAPAEDFFAFQKE 373

  Fly   559 EIDST----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYE 619
            .:|.:    :.:|.|||:|.:::::|||...|:.:|.||.:.|.::.|:...|.|..:.|...||
Human   374 PLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYE 438

  Fly   620 NACKLMAKQKVALECLSYHATASQDQTEKL--TQDV--------------------IAEAESYNL 662
            :..||..::.:..:.:.||.....::.:|:  |::|                    :.:|:.|.:
Human   439 SMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEI 503

  Fly   663 YSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVA 727
            ..|.|:|..|.:.:..:..::|:.:..:|.:|.||.:.|.|::.|:.|.||.:.||||||..||.
Human   504 NKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVG 568

  Fly   728 QTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFD 792
            ||||::|.|||::|:.||||.|.::.|..|||:|||||||.:|.|:::|||.|:.:|.:|.||.:
Human   569 QTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLE 633

  Fly   793 QCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVE-----NGEFDWQ 852
            ....:|..|..||||.|:...:...:..::.||::||||:|||||..|.::|:     ..|.:|.
Human   634 FGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWT 698

  Fly   853 -----GEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDR 912
                 .:.:|:::..|||||||:|||.||||||.:||.|||.||::|||||:..|...|:.||||
Human   699 QYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDR 763

  Fly   913 ERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVE 966
            .:.|||||:||||||.:|..:|:........|||:.:|...||:.|:.||::.:
Human   764 NKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYD 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	47/158 (30%)
		GAF	431..619	CDD:214500	42/205 (20%)
		PDEase_I	717..950	CDD:459723	116/242 (48%)
PDE6A	NP_000431.2	GAF	75..232	CDD:214500	47/159 (30%)
		GAF	254..441	CDD:214500	44/208 (21%)
		PDEase_I	558..802	CDD:459723	116/243 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..860