DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and PDE4C

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_000914.2	Gene:	PDE4C / 5143	HGNCID:	8782	Length:	712	Species:	Homo sapiens

Alignment Length:	687	Identity:	177/687 - (25%)
Similarity:	275/687 - (40%)	Gaps:	136/687 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 NGCMEFD-EHDVEIFRRYL---TFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECL 435
            :.|..|| |:.:...||.|   :..|:|    ::.:..|...:|.:..|..:.|.:|       |
Human    77 SSCRRFDLENGLSCGRRALDPQSSPGLG----RIMQAPVPHSQRRESFLYRSDSDYE-------L 130

  Fly   436 VTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVL 500
            ..|.|:         |.|....||      |.|.:|..|......::::..|......|.:.
Human   131 SPKAMS---------RNSSVASDL------HGEDMIVTPFAQVLASLRTVRSNVAALARQQC--- 177

  Fly   501 FELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQ--TVNICDVIEWVRDH-NQIRAEDEIDS 562
              ||...|.. |..||    ||:.|..    ...|||  .:...|.::|..|. ..::....:..
Human   178 --LGAAKQGP-VGNPS----SSNQLPP----AEDTGQKLALETLDELDWCLDQLETLQTRHSVGE 231

  Fly   563 TQAILCMPIMNAQKKVIGVAQLINKANGV------PFTDSDASIFEAFAIFCGLGIHNTQMYENA 621
            ..:.....|:|  :::..:::.....|.|      .|.|....: |...:..          |.|
Human   232 MASNKFKRILN--RELTHLSETSRSGNQVSEYISRTFLDQQTEV-ELPKVTA----------EEA 283

  Fly   622 CKLMAKQKVALECLSYHATASQ----------DQTEKLTQDVIAEAESYNLYSF-TFTDFELVDD 675
            .:.|::.. .|..|.:.|:.|.          ||.|:|.:    |.|..|.:.. .|...||..:
Human   284 PQPMSRIS-GLHGLCHSASLSSATVPRFGVQTDQEEQLAK----ELEDTNKWGLDVFKVAELSGN 343

  Fly   676 DTCRAVL-RMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGK 738
            ....|:: .:|.:.:|:..||||.|.|..::|.:..:|.. |.|||..||.:|||:...:|.|..
Human   344 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPA 408

  Fly   739 MERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEG 802
            :|...||||||..|.|...||:||.|.:|.|...|.|.||::|. .|.:|:||......:|.:|.
Human   409 LEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN 473

  Fly   803 NNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMT- 866
            .:|||.||.:...|:.:.|...:|:||::   |..|...:|      ....|.||....|:::.
Human   474 CDIFQNLSAKQRLSLRRMVIDMVLATDMS---KHMNLLADL------KTMVETKKVTSLGVLLLD 529

  Fly   867 --------------ACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKD 916
                          ..|:|...||..:..:....:..|||.|||.|:.. |:..|  |.|:...
Human   530 NYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHTA- 591

  Fly   917 ELPKMQVGFIDVICLPLYRVLCD-TFPWITPLYEGTLENRRNW----------------QDLAEK 964
            .:.|.||||||.|..||:....| ..|....|.: |||:.|.|                :|..::
Human   592 SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLD-TLEDNREWYQSKIPRSPSDLTNPERDGPDR 655

  Fly   965 VEMGLTWIDHDTIDKPVE---EFAACADE--EIKDIE 996
            .:..||..:.:..|:..|   |..|.|.|  |:.|.|
Human   656 FQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	9/34 (26%)
		GAF	431..619	CDD:214500	35/196 (18%)
		PDEase_I	717..950	CDD:278654	82/250 (33%)
PDE4C	NP_000914.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..64
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..200		7/27 (26%)
		PDEase_I	387..628	CDD:278654	83/253 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..655		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..712		9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820