DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde6 and PDE4B

DIOPT Version :9

Sequence 1:NP_001262566.1 Gene:Pde6 / 41760 FlyBaseID:FBgn0038237 Length:1124 Species:Drosophila melanogaster
Sequence 2:NP_001032418.1 Gene:PDE4B / 5142 HGNCID:8781 Length:736 Species:Homo sapiens


Alignment Length:671 Identity:158/671 - (23%)
Similarity:264/671 - (39%) Gaps:157/671 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   466 HLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGG--EYQAANVSRPSVS---------- 518
            |.:.:|..|......:::|        :||.||:|..|.|  ..::...|:|.||          
Human   160 HGDDLIVTPFAQVLASLRS--------VRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQ 216

  Fly   519 ELSSSTLAQ----------IAQFVATTGQTVN---------ICDVIEWVRDHNQI---------- 554
            :|:..||.:          |..:.:.:....|         :..:.|..|..||:          
Human   217 KLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD 281

  Fly   555 -RAEDEIDS-TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQM 617
             :.:.||.| ||       .:.:||  ...||:.:.:||.                         
Human   282 KQNDVEIPSPTQ-------KDREKK--KKQQLMTQISGVK------------------------- 312

  Fly   618 YENACKLMAKQKVALECLSYHA--TASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRA 680
                 |||....:....:|...  |.::|...|..:|:    ..:.|..|....:......|| .
Human   313 -----KLMHSSSLNNTSISRFGVNTENEDHLAKELEDL----NKWGLNIFNVAGYSHNRPLTC-I 367

  Fly   681 VLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMT 744
            :..:|.:.:|:..|:|..|....:::::..:|. .|.|||..||.:|||:...:|.|..::...|
Human   368 MYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFT 432

  Fly   745 DLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQA 808
            |||||..:.|...||:||.|.:|.|...|.|.||::|. .|.:|:||......:|..|..:||..
Human   433 DLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 497

  Fly   809 LSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMT 866
            |:.:..:::.|.|...:|:||::.:.........:||..:....|       .::..:|..|:..
Human   498 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHC 562

  Fly   867 ACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVIC 930
            | |:|...|..|:..:....:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.|.
Human   563 A-DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP--MCDKHTA-SVEKSQVGFIDYIV 623

  Fly   931 LPLYRVLCDTFPWITPLYE---GTLENRRNW-QDLAEKVEMGLTWIDHDTIDKPVEEFAACADEE 991
            .||:....|.   :.|..:   .|||:.||| |.:..:           :...|::|........
Human   624 HPLWETWADL---VQPDAQDILDTLEDNRNWYQSMIPQ-----------SPSPPLDEQNRDCQGL 674

  Fly   992 IKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSG-SRLSMKKTGALGKAVRSKLSKTLYNSMDGSK 1055
            ::..:|.:|.         ..|||..||.:..| |..|..||..:               :|   
Human   675 MEKFQFELTL---------DEEDSEGPEKEGEGHSYFSSTKTLCV---------------ID--- 712

  Fly  1056 PKTSLKLLESHVSEDMDDKSP 1076
            |:....|.|:.:....:||||
Human   713 PENRDSLGETDIDIATEDKSP 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde6NP_001262566.1 GAF 247..406 CDD:214500
GAF 431..619 CDD:214500 35/195 (18%)
PDEase_I 717..950 CDD:278654 75/244 (31%)
PDE4BNP_001032418.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..209 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..301 7/27 (26%)
PDEase_I 405..646 CDD:278654 76/247 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..736 18/67 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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