Protein Alignment Pde6 and PDE4A

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_001104777.1
• Gene: PDE4A / 5141
• HGNCID: 8780
• Length: 886
• Species: Homo sapiens
• Alignment Length: 874
• Identity: 190/874 - (21%)
• Similarity: 324/874 - (37%)
• Gaps: 261/874 - (29%)

  Fly   260 GLLTHA-----DRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDA--VTRASAEEIII-PFGIGIA 316
            ||:.||     .|...||        |.....:|::.||..:::  .:.|.||::|: ||...:|
Human   130 GLVLHAGAATSQRRESFL--------YRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLA 186

  Fly   317 GMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFD 381
            .:              :..|.|..:      .||    :|:.:.:...:|     ..|..|
Human   187 SL--------------RSVRSNFSL------LTN----VPVPSNKRSPLG-----GPTPVC---- 218

  Fly   382 EHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEAREL 446
                               .|.|.|.:.|:         |||...||
Human   219 -------------------KATLSEETCQQ---------LARETLEE------------------ 237

  Fly   447 LKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAAN 511
                        ||.|    ||::   ......|::....|.:.|:|.||     ||
Human   238 ------------LDWC----LEQL---ETMQTYRSVSEMASHKFKRMLNR-----EL-------- 270

  Fly   512 VSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAED----EIDSTQAIL----- 567
               ..:||:|.|. .|::::::||           ::...|::....    |.:..||..
Human   271 ---THLSEMSRSG-NQVSEYISTT-----------FLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 320

  Fly   568 ----CMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQ 628
                .:|.:....::.|:.:|::..:                      ::|:.:.....|
Human   321 PPPPPVPHLQPMSQITGLKKLMHSNS----------------------LNNSNIPRFGVK----- 358

  Fly   629 KVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQ 693
                          .||.|.|.|: :.....:.|..|..:|:......|| .:..:|.:.:|:.:
Human   359 --------------TDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTC-IMYMIFQERDLLKK 407

  Fly   694 FQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLC 757
            |:||.|.:..::|::..:|. .|.|||..||.:|.|:...:|.|..::...||||||..|.|...
Human   408 FRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAI 472

  Fly   758 HDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTV 821
            ||:||.|.:|.|...|.|.||::|. .|.:|:||......:|..:..:|||.||....:|:.|.|
Human   473 HDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMV 537

  Fly   822 ESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAKPWEV 879
            ...:|:||::.:.........:||..:....|       .::..:|..|:..| |:|...||.|:
Human   538 IDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTKPLEL 601

  Fly   880 QHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFP 942
            ..:....:..|||.|||.|:.: :...|  |.|:... .:.|.||||||.|..||:....| ..|
Human   602 YRQWTDRIMAEFFQQGDRERERGMEISP--MCDKHTA-SVEKSQVGFIDYIVHPLWETWADLVHP 663

  Fly   943 WITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEE--------------FAACADEEIK 993
            ....:.: |||:.|:|...|         |.......|.||              |....:|| :
Human   664 DAQEILD-TLEDNRDWYYSA---------IRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEE-E 717

  Fly   994 DIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKT 1058
            :.|.::..:.|..|.                   ::...|..|  |...|..|:  :.:.|..:.
Human   718 EEEISMAQIPCTAQE-------------------ALTAQGLSG--VEEALDATI--AWEASPAQE 759

  Fly  1059 SLKLLESHVSEDMDDKSPTSPSQPQASGS 1087
            ||:::....|.:.:.::.....|.|::||
Human   760 SLEVMAQEASLEAELEAVYLTQQAQSTGS 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	28/153 (18%)
		GAF	431..619	CDD:214500	28/200 (14%)
		PDEase_I	717..950	CDD:459723	78/242 (32%)
PDE4A	NP_001104777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..128
		PDE4_UCR	178..293	CDD:465648	40/240 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..331		5/36 (14%)
		PDEase_I	432..672	CDD:459723	78/244 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..705		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..886