DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and PDE1A

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_016859783.1	Gene:	PDE1A / 5136	HGNCID:	8774	Length:	586	Species:	Homo sapiens

Alignment Length:	498	Identity:	126/498 - (25%)
Similarity:	217/498 - (43%)	Gaps:	89/498 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 GIHNTQMYENACKLMAKQKVALECLSYHAT--ASQDQTEKLTQDVIAEAESYNLYSFTFTDFELV 673
            ||...:||.....::.        |:|.|.  .:....:|.:.||.|..|:...:|..|..:||
Human   128 GIFVERMYRKTYHMVG--------LAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYEL- 183

  Fly   674 DDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM-FAMLK 735
                       |.:.:|:::|:||...|..:..::...|...|  |||..||.:|.||: :.||.
Human   184 -----------FTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLH 237

  Fly   736 TGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILN 799
            ||.| .::|:||||.::.|...||.:|.||.|.|..:|.|.:||||. .|.:|:||......::.
Human   238 TGIM-HWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301

  Fly   800 SEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMM 864
            .|..||...||.:|:|.:...|...:||||::.:|::    ::.:.|.....:|.::...: .::
Human   302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKTM-SLI 361

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDEL-PKMQVGFID 927
            :.|.|:|..||.|::.::....:.:|||.|||.| :|.|...|:.    :||..: .:.|:||||
Human   362 LHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC----DRKSTMVAQSQIGFID 422

  Fly   928 VICLPLYRVLCD-TFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEE 991
            .|..|.:.:|.| |...:.||.|.           |.|.|              ...:.|.:...
Human   423 FIVEPTFSLLTDSTEKIVIPLIEE-----------ASKAE--------------TSSYVASSSTT 462

  Fly   992 IKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKP 1056
            |..:.........|.:... |:.|::|::..:...|         |:.::.|...:..:.:..|.
Human   463 IVGLHIADALRRSNTKGSM-SDGSYSPDYSLAAVDL---------KSFKNNLVDIIQQNKERWKE 517

  Fly  1057 KTSLKLLESHV---------------SEDMDDKSPTSPSQPQA 1084
            ..:..|...||               ..::.:::|..|.|..|
Human   518 LAAQALSSDHVLYHVSSTIEQEYAFDRVELSEETPCVPVQTNA 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	3/7 (43%)
		PDEase_I	717..950	CDD:278654	81/237 (34%)
PDE1A	XP_016859783.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920