DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and PDE11A

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_058649.3	Gene:	PDE11A / 50940	HGNCID:	8773	Length:	933	Species:	Homo sapiens

Alignment Length:	950	Identity:	381/950 - (40%)
Similarity:	537/950 - (56%)	Gaps:	101/950 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGA----IPASSSSGNQVKLEHHHRQSNNNRPA 90
            |...:|...|.:..|.||..||.:.|...||...|    :|.....|
Human    48 ALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCG------------------ 94

  Fly    91 VTNRSSETKLMTPTGSSSSPS-QSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKP 154
                          |...||| ...|:...::|.:.||:: |.|   :.::.....|.|.::|:
Human    95 --------------GVPLSPSWAGGSRGDGNLQRRASQKE-LRK---SFARSKAIHVNRTYDEQ- 140

  Fly   155 EAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSL 219
                  :|.|| .|.||.::.....||....|..|:.:....:.:...:.:..|.::
Human   141 ------VTSRA-QEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAI-------- 190

  Fly   220 PECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPT-NKYLV 283
             :.:.||...:|.:.|:||::|::|:||:..|.:|||:.|.|:..|||.||||.:|... .|.||
Human   191 -DYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLV 254

  Fly   284 AKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYK 348
            :|.|||...|.|....:..::.|:.:|:|.||.|.|.:..:.:||.:||:|.|||.|||..||||
Human   255 SKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYK 319

  Fly   349 TNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYR 413
            |.::|||||.:.:|:||||||.|||......|.|.|.::.:.||.||||.|.|||||..|.:||.
Human   320 TKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384

  Fly   414 RNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPA 478
            |::.||.:...:||||.:||.:|.|||..|:.|||||||||.|::           .||.|
Human   385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE-----------DIESP---- 434

  Fly   479 TRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLA---QIAQFVATTGQTVN 540
              .:|...|||          |........|.|..:.|:.:.|.|...   .||:.||:||..||
Human   435 --VVKFTKSFE----------LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVN 487

  Fly   541 ICDVIEWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASI 600
            |.|.      :...|.:.|.|.     .:::||:||.|:..::|||||::|:.:|.||.|:|..:
Human   488 ISDA------YQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRL 546

  Fly   601 FEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSF 665
            ||||.|||||||:||.||:...|..|||.|||:.||||||.|:.:.:|.....|.......:...
Human   547 FEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDI 611

  Fly   666 TFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTM 730
            .|.||.|..|....|.|||||:..:|.:|:|.|:.||||:|:||||||.|.|||||||.||.|.|
Human   612 HFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 676

  Fly   731 FAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHHHFDQC 794
            ||||.|...:..:|::|||.::|.||||||||||||||||.|:.|.||.|| |::|:|||||:..
Human   677 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHA 741

  Fly   795 VMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDL 859
            ||||.|||:|||..||.::|..:|:.::.:||:|||.:||::|..|.|||..||:||..:..:|:
Human   742 VMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDI 806

  Fly   860 LCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVG 924
            ...|:|||||:.|:.||||:..:||:||..|||:|||.|:|:|...|.|:.||.||||||::|:.
Human   807 FRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871

  Fly   925 FIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEK 964
            :||.||:|||:.|......:.|:.:....||..|::|.:|
Human   872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	76/159 (48%)
		GAF	431..619	CDD:214500	73/195 (37%)
		PDEase_I	717..950	CDD:278654	125/233 (54%)
PDE11A	NP_058649.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..125		24/112 (21%)
		GAF	217..380	CDD:214500	77/162 (48%)
		GAF	402..568	CDD:214500	74/198 (37%)
		PDEase_I	663..898	CDD:278654	125/234 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56763
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3659
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	1	1.000	-	-		otm40818
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780