DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde6c

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001101992.1	Gene:	Pde6c / 361752	RGDID:	1309844	Length:	861	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	306/968 - (31%)
Similarity:	473/968 - (48%)	Gaps:	162/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DEVARLFEEKP----EAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQ 204
            |.|.|..||.|    |.|:|.|....|                       ..:|:...|.   ||
  Rat     7 DAVERYLEENPCFAKEYFDKKLRVETP-----------------------GAIFKNSHAG---VQ 45

  Fly   205 QKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANEL-DIDVLCHKILVNVGLLTHADRG 268
                      :.:|||    .:..::|..|.:||::.:.:|. ..:.:.|:.|..:..|..|:..
  Rat    46 ----------AGTSLP----RMTQVEESALCLELLQHMQDETGSAEQVAHRALQRLARLLQAECC 96

  Fly   269 SLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYK 333
            |:|..:.......:.::|.:||..:..:|.:. |...|::.|..|||.|.||..|:.:|:....|
  Rat    97 SMFSCRSRNGIPEVASRLLNVTPTSKFEDNLV-APNREVVFPLDIGIVGWVAHVKKALNVSNVKK 160

  Fly   334 DARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIG 398
            ::.|:..:|.:|||.|..:|.:||...: :::.|...:||.| ..||.:.|.|:|.:||:|..|.
  Rat   161 NSHFSDFMDKQTGYVTRNLLAVPIMTGK-EVLAVVMAVNKIN-APEFSKQDEEVFSKYLSFVAIA 223

  Fly   399 IQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCE 463
            ::......:...|.||:|||:..|..:|||..::|....|.:...|..|.|||.|:.|:|:...:
  Rat   224 LRLQHTSYLYSVESRRSQILMWSANKVFEELTDVERQFHKALYTVRTYLNCERYSIGLLDMTKEK 288

  Fly   464 ASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFE------LGGEYQAANVSRPSVSELSS 522
            ..:.|..|:.......:..|:.|..|         ::|.      |.|:.:.:.:..|.....
  Rat   289 EFYDEWPIKLGEVEPYKGPKTPDGRE---------IIFYKIIDYILHGKEEISVIPSPPADHW-- 342

  Fly   523 STLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDST----QAILCMPIMNAQKKVIGVAQ 583
            :.::.:..::|..|   .||:::....|......:..:|.|    :.:|.:||:|.::.::|||.
  Rat   343 TLVSGLPTYIAENG---FICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVAT 404

  Fly   584 LINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLS--YHATASQDQT 646
            ..|:.:|.||.:.|..|.|....|.|..:.||..||...||.:::.:|.|.:.  ..||.|:..:
  Rat   405 FYNRKDGKPFDEHDEHITETLTQFLGWSLLNTDTYERVNKLESRKDIAQEMIMNLTKATPSEISS 469

  Fly   647 -----EKLTQDVIAEAE----------------SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNL 690
                 |||..|||.|.|                :.:||.|.|:||.:.:.:..:..||:|::.|:
  Rat   470 ILKFKEKLNIDVIEECEERQLLAILKEELPDPRAADLYEFRFSDFPVTEHELVKCGLRLFLEINV 534

  Fly   691 VSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVAC 755
            |.:|::|.:||.||:.:|||.||||.||||||..||.||||.:|.||:::::.||||...:|.|.
  Rat   535 VEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAA 599

  Fly   756 LCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKT 820
            .|||:|||||||.:|.|:.||||.|:.||.:|.||.:....:|..|..||||.||...:.:|:..
  Rat   600 FCHDIDHRGTNNLYQMKSTSPLARLHGTSILERHHLEYSKTLLQDESLNIFQNLSKRQFETVIHL 664

  Fly   821 VESAILSTDLAMYFKKRNAFLELVENGEFDWQGEE-----------KKDLLCGMMMTACDVSAIA 874
            .|.||::||||:|||||..|.::|:..| ..|.||           ||:::..|||||||:|||.
  Rat   665 FEVAIIATDLALYFKKRTMFQKIVDTCE-QMQSEEETIKYVTADPTKKEVIMAMMMTACDLSAIT 728

  Fly   875 KPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD 939
            ||||||.:...|||:||::|||||:..|..||:.||||.:|.||||:||||||.:|..:|:....
  Rat   729 KPWEVQSQATLLVANEFWEQGDLERTVLQQQPIPMMDRNKKGELPKLQVGFIDFVCTFVYKEFSR 793

  Fly   940 TFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNC 1004
            ....|||:..|...||..|:.|||:.|..:                ...:||:
  Rat   794 FHGEITPMLTGLQNNRVEWKSLAEEYEAKV----------------KVTEEEV------------ 830

  Fly  1005 NQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKL 1062
                  |.::..|.:                |||     :..|.:|.|..|.||.|.|
  Rat   831 ------GKQEEVTSD----------------GKA-----ATDLGSSTDDKKSKTCLML 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	44/158 (28%)
		GAF	431..619	CDD:214500	44/197 (22%)
		PDEase_I	717..950	CDD:278654	121/243 (50%)
Pde6c	NP_001101992.1	GAF	81..232	CDD:214500	44/153 (29%)
		GAF	256..443	CDD:214500	46/200 (23%)
		PDEase_I	561..806	CDD:278654	122/245 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930