Protein Alignment Pde6 and Pde8a

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_063118773.1
• Gene: Pde8a / 308776
• RGDID: 735125
• Length: 858
• Species: Rattus norvegicus
• Alignment Length: 758
• Identity: 142/758 - (18%)
• Similarity: 266/758 - (35%)
• Gaps: 224/758 - (29%)

  Fly   235 FMELIRDV-------ANELDIDVLCHKI--------LVNVGLLTHADRGSL----FLAKGTPTNK 280
            |.:.:.|:       ..::|.:.:|..|        .|.||::...|:..:    |||.|. |.:
  Rat   114 FQDKLHDIIIIDHRNPRQMDAEAMCRSIRSSKLSENTVIVGVVRRVDKEEVSLMPFLAAGF-TRR 177

  Fly   281 YL----------------------------VAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAG 317
            |:                            ...:|...:|:  ::|:...|.:.||
  Rat   178 YIENPNVMACYNELLQLAFGEVRSQLKLRACNSVFTALEKS--QEAIEITSEDHII--------- 231

  Fly   318 MVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAIL-----CMPICNYEGDIIGVAQIINKTNGC 377
                         .|.:..|    :...||::..::     .:||...:||      :::..|.|
  Rat   232 -------------QYANPAF----ETTMGYQSGELIGKELAQVPINEKKGD------LLDAINSC 273

  Fly   378 MEFDEHDVEIFRRYLTFCGIGI-QNAQLFEMSVQ--EYRRNQILLNLARSIFEEQNNLECLVTKI 439
            :..|:....::..... .|..| ||.::..:..|  :.|....::.:.....:.:...||:.|..
  Rat   274 VTIDKEWQGVYHTQKK-NGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGSNKVETTTECVQTDS 337

  Fly   440 MTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELG 504
            .|:::                  ...|.::   :.:....:|:.|..|  |...:.|.:.|..:
  Rat   338 QTDSQ------------------AGKHKDR---RKHSMDVKAVSSRTS--EVSNQRRHSSLARI- 378

  Fly   505 GEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHN-QIRAEDEIDSTQAILC 568
               .:..:..|....::..:.||....|:.|....::.|::.....:: |...||:..:|..:
  Rat   379 ---HSMMIEAPITKVINILSAAQENSPVSVTEALNHVLDILRTTELYSPQFNTEDDPHATDLV-- 438

  Fly   569 MPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALE 633
                                 |...:|             ||...:...|..|.|.:......|.
  Rat   439 ---------------------GGLMSD-------------GLRRFSGNEYTLATKSLRPSSSQLA 469

  Fly   634 C-LSYHATASQDQTEKLTQDVIAEAESYNLYSF-----------------TFTDFELVDDDTCRA 680
            . :|.|     |...::.| ||...|.::...|                 ||..||:.:
  Rat   470 VPISLH-----DIPPRIAQ-VIENEEQWDFDIFELEAATQNRPLIYLGLKTFARFEICE------ 522

  Fly   681 VLRMFMQCN---LVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMER 741
                |:||:   |.|.|||           :..||.... |||..||.:|.......|...|::.
  Rat   523 ----FLQCSEATLKSWFQI-----------IESNYHSSNPYHNSTHAADVLHATAYFLSRNKLKD 572

  Fly   742 FMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMI-LNSEGNN 804
            .:..|:.:..|:|...||:||.|..|:|.......||:||. |:.:|.||......: |.::..|
  Rat   573 TLDRLDEVAALIAATIHDVDHPGRTNSFLCNAGKELAVLYNDTAVLESHHAALAFQLTLENDKCN 637

  Fly   805 IFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELV------ENGEFDWQGE--------- 854
            ||:.....|||::.:::...:|:|::..:|:..|.|:..:      :..|....|.
  Rat   638 IFKNTDRNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLKAQKNEVQETGRSLEDIRAMV 702

  Fly   855 ---EKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQ 894
               |.:.|:..||:...|||...:|.|...:.|..:::|:|.|
  Rat   703 RTPESRTLIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQ 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	34/204 (17%)
		GAF	431..619	CDD:214500	25/188 (13%)
		PDEase_I	717..950	CDD:459723	53/198 (27%)
Pde8a	XP_063118773.1	None