DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and Pde1b

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_073201.1	Gene:	Pde1b / 29691	RGDID:	3278	Length:	535	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	110/408 - (26%)
Similarity:	184/408 - (45%)	Gaps:	85/408 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 NLYSFTFTDFEL---VDDDTCRA-VLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHN 719
            ||..:.|..|.|   .||...|. |..:..:.:|:|:|:||...|..::.::...|...|  |||
  Rat   159 NLDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHN 223

  Fly   720 WRHALNVAQTMFA-MLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT- 782
            ..||.:|.||:.. :|:|| |...::::|:|.::.|...||.:|.||.|:|..:|:|..||||.
  Rat   224 QIHAADVTQTVHCFLLRTG-MVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYND 287

  Fly   783 TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYF---KKRNAFLELV 844
            .|.:|:||......::..:..|||..|:.:::..:...|...:|:||::.:|   |.....|:.:
  Rat   288 RSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQL 352

  Fly   845 ENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVA 908
            |..:        |.....:::.|.|:|...|.|.|..:..|.:.:|||.|||.| :|.|...|:.
  Rat   353 ERID--------KSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLC 409

  Fly   909 MMDRERKDEL-PKMQVGFIDVICLPLYRVLCD--------------------TFPWITPLYEGTL 952
                :|...| .:.|:||||.|..|.:.||.|                    :|.|..|..:..:
  Rat   410 ----DRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVDV 470

  Fly   953 -------------------ENRRNWQDLAEKVEMGLTWIDHDTIDK--PVEEFAACADEEIKDIE 996
                               ||::.|:   |:...|:|  :..:||:  |.||.|..:..|
  Rat   471 GDPNPDVVSFRSTWTKYIQENKQKWK---ERAASGIT--NQMSIDELSPCEEEAPSSPAE----- 525

  Fly   997 FTVTTLNCNQQSQHGSED 1014
                    ::.:|:|:.|
  Rat   526 --------DEHNQNGNLD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500
		PDEase_I	717..950	CDD:278654	77/259 (30%)
Pde1b	NP_073201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Calmodulin-binding. /evidence=ECO:0000255	27..47
		PDEase_I_N	80..136	CDD:400687
		PDEase_I	221..448	CDD:395177	74/239 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..474		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..535		13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920