DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and Pde4c

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001263694.1	Gene:	Pde4c / 290646	RGDID:	727918	Length:	671	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	108/336 - (32%)
Similarity:	161/336 - (47%)	Gaps:	38/336 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 DQTEKLTQDVIAEAESYNLYSF-TFTDFELVDDDTCRAVL-RMFMQCNLVSQFQIPYDVLCRWVL 706
            ||.|:|.:    |.|..|.:.| .|...||..:....||: .:..:.:|:..||||.|.|.|::|
  Rat   316 DQEEQLAK----ELEDTNKWGFDVFKVAELSGNRPLTAVIFSVLQERDLLKTFQIPADTLLRYLL 376

  Fly   707 SVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQ 770
            ::..:|.. |.|||..||.:|.|:...:|.|..:|...||||:|..:.||..||:||.|.:|.|.
  Rat   377 TLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFL 441

  Fly   771 TKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYF 834
            ..|.|.||::|. :|.:|:||......:|..|..:|||.||.:...|:.:.|...:|:||::.:.
  Rat   442 INTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHM 506

  Fly   835 KKRNAFLELVENGEFDWQGEEKKDLLCGMMMT---------------ACDVSAIAKPWEVQHKVA 884
            ........:||.         ||....|:::.               ..|:|..|||..:..:..
  Rat   507 SLLADLKTMVET---------KKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWT 562

  Fly   885 KLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFPWITPL 947
            :.:..|||.|||.|:.. |:..|  |.|:... .:.|.||||||.|..||:....| ..|....|
  Rat   563 ERIMAEFFQQGDRERESGLDISP--MCDKHTA-SVEKSQVGFIDYIAHPLWETWADLVHPDAQEL 624

  Fly   948 YEGTLENRRNW 958
            .: |||:.|.|
  Rat   625 LD-TLEDNREW 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500
		PDEase_I	717..950	CDD:278654	79/250 (32%)
Pde4c	NP_001263694.1	PDEase_I	388..629	CDD:278654	80/253 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820