DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde6b

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001099494.1	Gene:	Pde6b / 289878	RGDID:	1311039	Length:	856	Species:	Rattus norvegicus

Alignment Length:	885	Identity:	283/885 - (31%)
Similarity:	461/885 - (52%)	Gaps:	109/885 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SVTSDLFQQWMAASPTV------QQKSPRSLSNS-SASSLPEC--RRHLMDLDEGELFMELIRDV 242
            |::.:..:.::..:||.      ::.||.:::.: ....|.:|  .|.|..::|.....||::|:
  Rat     2 SLSEEQVRSFLDGNPTFAHQYFEKKLSPENVAGACEGGCLVDCGSLRELCQVEESAALFELVQDM 66

  Fly   243 ANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEI 307
            ...::::.:..|:|..:..:.||||.|||:.:.......|..:||.|...:.|:|.:....: ||
  Rat    67 QESVNMERVVFKVLRRLCTILHADRCSLFMYRQRNGVAELATRLFSVQPDSLLEDCLVPPDS-EI 130

  Fly   308 IIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIIN 372
            :.|..|||.|.|||||:|||:::..:...|:...|..|.|.|..||..||.|.: |::.|...:|
  Rat   131 VFPLDIGIVGHVAQTKKMINVQDVAECPHFSPFADELTDYVTKNILSTPIMNGK-DVVAVIMAVN 194

  Fly   373 KTNG-CMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLV 436
            |.:| |  |...|.::|.:||.|..:.::...|..:...|.||.|:||..|..:|||..::|...
  Rat   195 KLDGPC--FTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQF 257

  Fly   437 TKIMTEARELLKCERCSVFLVDLDCCEASHLEKII--------------EKPNQPATRAI---KS 484
            .|.....|..|.|:|.||.|:|:.      .||..              ..|..|..|.|   |.
  Rat   258 HKAFYTVRAYLNCDRYSVGLLDMT------KEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKV 316

  Fly   485 ADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSE--LSSSTLAQIAQFVATTGQTVNICDVIEW 547
            .|              :.|.|:.....:..|....  |:|.    :..:||.:|   .||:::..
  Rat   317 ID--------------YILHGKEDIKVIPTPPADHWALTSG----LPTYVAESG---FICNIMNA 360

  Fly   548 VRDHNQIRAEDEIDST----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFC 608
            ..|......|..:|.:    :.:|.|||:|.:::::|||...|:.:|.||.|.|..:.|:...|.
  Rat   361 SADEMFNFQEGPLDESGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFL 425

  Fly   609 GLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKL--TQDVI----AEAE--------- 658
            |..:.||..|:...||..::.:|.:.:.||....:|:.:::  |:|.:    |:.|
  Rat   426 GWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILK 490

  Fly   659 -------SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK 716
                   .:::|.|.|:|.|..:.:..:..::|:.:..:|.:||||.:||.|::.||.|.||.:.
  Rat   491 EELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRIT 555

  Fly   717 YHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 781
            ||||||..|||||||.:|.|||::.:.||||...::.|.||||:|||||||.:|.|:::|||.|:
  Rat   556 YHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620

  Fly   782 TTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVEN 846
            .:|.:|.||.:....:|..|..||:|.|:...:..|:..::.||::||||:|||||..|.::|:.
  Rat   621 GSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDE 685

  Fly   847 GEFDWQGEE-----------KKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKL 900
            .: :::.::           :|:::..|||||||:|||.||||||.|||.|||.||::|||||:.
  Rat   686 SK-NYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERT 749

  Fly   901 QLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKV 965
            .|:.||:.||||.:..||||:||||||.:|..:|:........|.|:::....||:.|:.||::.
  Rat   750 VLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814

  Fly   966 EMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCN 1005
            |..:..::.   :|..||....|.:...:|        ||
  Rat   815 EAKVKALEE---EKKKEEDRVAAKKAGTEI--------CN 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	53/159 (33%)
		GAF	431..619	CDD:214500	50/210 (24%)
		PDEase_I	717..950	CDD:278654	114/243 (47%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500	53/162 (33%)
		GAF	252..439	CDD:214500	51/213 (24%)
		PDEase_I	556..801	CDD:278654	114/245 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930