DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and PDE7B

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_061818.1	Gene:	PDE7B / 27115	HGNCID:	8792	Length:	450	Species:	Homo sapiens

Alignment Length:	379	Identity:	99/379 - (26%)
Similarity:	172/379 - (45%)	Gaps:	34/379 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 FCGLGIHNTQMYENACKLMAKQKVALECLSY-HAT------ASQDQTEKLTQDVIAEA----ESY 660
            |....:.|:..|........|.|..|....| ||:      ..|.....|.:|.:.:|    ...
Human    48 FIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKV 112

  Fly   661 NLYSFTFTDFELVDDDTCRAVL--RMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRH 722
            .::.|....|:.:.:......|  .:|....|:..|::....|.|:::.|:::|.... |||..|
Human   113 GMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVH 177

  Fly   723 ALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTM 786
            |.:|.|.|...||..|:..|:|.|:|:..|:|...||:||.|.|..|..||...||.|| ..|.:
Human   178 AADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVL 242

  Fly   787 EHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVE----NG 847
            |:||:...:.:|..  :.:...|..|..:.:.:.:.|.||:||:    .::|.||..::    |.
Human   243 ENHHWRSTIGMLRE--SRLLAHLPKEMTQDIEQQLGSLILATDI----NRQNEFLTRLKAHLHNK 301

  Fly   848 EFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMD 911
            :...:..:.:..:..:.:...|:....:.||:..:.::.|.:||:.||:|| |.:|...|:.
Human   302 DLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLC--- 363

  Fly   912 RERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTL----ENRRNWQDL 961
            .::||.:|.:|:||:..|..||:|.... |...:.|.|..|    .|:..|:.|
Human   364 NQQKDSIPSIQIGFMSYIVEPLFREWAH-FTGNSTLSENMLGHLAHNKAQWKSL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	2/11 (18%)
		PDEase_I	717..950	CDD:278654	71/238 (30%)
PDE7B	NP_061818.1	PDEase_I	172..392	CDD:278654	69/229 (30%)
PDE7B	NP_061818.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820