DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde4a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_037233.4	Gene:	Pde4a / 25638	RGDID:	3279	Length:	844	Species:	Rattus norvegicus

Alignment Length:	1083	Identity:	228/1083 - (21%)
Similarity:	378/1083 - (34%)	Gaps:	326/1083 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 MTPTGSSSSPSQS-----PSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKW 160
            |.|..:.|..|.|     |.:.||:::.......|..:......|:...:.|    |:.|
  Rat     1 MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSA----ERSE----- 56

  Fly   161 LTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAA------------------SPTVQQKS 207
             |||:|...:.|........:|..|.:..|     |.::                  .||   .|
  Rat    57 -TERSPHRPIERADAVDTGDRPGLRTTRMS-----WPSSFHGTGTGGGSSRRLEAENGPT---PS 112

  Fly   208 P-RSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHA-----D 266
            | ||..:|.||.                                         ||:.||     .
  Rat   113 PGRSPLDSQASP-----------------------------------------GLVLHAGATTSQ 136

  Fly   267 RGSLFLAKGTPTNKYLVAKLFDVTQKTALKDA--VTRASAEEIII-PFGIGIAGMVAQTKQMINI 328
            |...||        |.....:|::.|...:.:  .:.|.||::|: ||...:|.:
  Rat   137 RRESFL--------YRSDSDYDMSPKAVSRSSSVASEAHAEDLIVTPFAQVLASL---------- 183

  Fly   329 KEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLT 393
                :..|.|..:      .||    :||.:.:...:|....:.|
  Rat   184 ----RSVRSNFSL------LTN----VPIPSNKRSPLGGPPSVCK-------------------- 214

  Fly   394 FCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVD 458
                    |.|.|.:.|:         |||...||
  Rat   215 --------ATLSEETCQQ---------LARETLEE------------------------------ 232

  Fly   459 LDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSS 523
            ||.|    ||::   ......|::....|.:.|:|.||     ||           ..:||:|.|
  Rat   233 LDWC----LEQL---ETMQTYRSVSEMASHKFKRMLNR-----EL-----------THLSEMSRS 274

  Fly   524 TLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKA 588
            . .|::::::.|           ::...|::.........:|....|     ..|:..:|.:::.
  Rat   275 G-NQVSEYISNT-----------FLDKQNEVEIPSPTPRQRAFQQPP-----PSVLRQSQPMSQI 322

  Fly   589 NGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDV 653
            .|:...                 :|...:..|..:...|               .||.:.|.|:
  Rat   323 TGLKKL-----------------VHTGSLNTNVPRFGVK---------------TDQEDLLAQE- 354

  Fly   654 IAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKY 717
            :.....:.|..|..:::......:| .:..:|.:.:|:.:|.||.|.:..::|::..:|. .|.|
  Rat   355 LENLSKWGLNIFCVSEYAGGRSLSC-IMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAY 418

  Fly   718 HNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT 782
            ||..||.:|.|:...:|.|..::...||||||..|.|...||:||.|.:|.|...|.|.||::|.
  Rat   419 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 483

  Fly   783 -TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVEN 846
             .|.:|:||......:|..|..:|||.||....:|:.|.|...:|:||::.:.........:||.
  Rat   484 DESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET 548

  Fly   847 GEFDWQG-------EEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LN 903
            .:....|       .::..:|..|:..| |:|...||.|:..:....:..|||.|||.|:.: :.
  Rat   549 KKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME 612

  Fly   904 TQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD-TFPWITPLYEGTLENRRNW------QDL 961
            ..|  |.|:... .:.|.||||||.|..||:....| ..|....:.: |||:.|:|      |..
  Rat   613 ISP--MCDKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD-TLEDNRDWYHSAIRQSP 673

  Fly   962 AEKVEMGLTWIDHDTI-DKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRS-- 1023
            :..:|.....:.|.:: ||  .:|....:||.::....|..|...:::...:||:.......|
  Rat   674 SPPLEEEPGGLGHPSLPDK--FQFELTLEEEEEEDSLEVPGLPTTEETFLAAEDARAQAVDWSKV 736

  Fly  1024 ----------GSRLSMKKTGALG------KAVRSKLS---------KTLYNSMDG----SKPKTS 1059
                      ..||..:...|.|      :||....|         :||.:|.:.    ..|.|:
  Rat   737 KGPSTTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILPDVRTLSSSEEAPGLLGLPSTA 801

  Fly  1060 LKLLESHVSEDMDDKSPTSPSQPQASGSMGRMSASSSTSSAGG 1102
            .::      |...|....:.:....||:.|..||..||....|
  Rat   802 AEV------EAPRDHLAATRACSACSGTSGDNSAIISTPGRWG 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	27/166 (16%)
		GAF	431..619	CDD:214500	26/187 (14%)
		PDEase_I	717..950	CDD:278654	79/242 (33%)
Pde4a	NP_037233.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124		30/140 (21%)
		PDE4_UCR	173..288	CDD:407935	39/240 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..317		3/25 (12%)
		PDEase_I	418..659	CDD:395177	80/245 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820