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Protein Alignment Pde6 and Pde4d

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001106799.1	Gene:	Pde4d / 24627	RGDID:	3281	Length:	803	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	173/695 - (24%)
Similarity:	280/695 - (40%)	Gaps:	176/695 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 FEMSVQEYRRN------------------QILLNL--ARSIFEEQNNLE----------C---LV 436
            :::|.:...||                  |:|.:|  .|:.|....||:          |   .:
  Rat   194 YDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSI 258

  Fly   437 TK--IMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATR-AIKSADSFEEKKMRNRFT 498
            .|  |..||.:.|..|.    |.:||.| ...||.:       .|| ::....|.:.|:|.||
  Rat   259 NKATITEEAYQKLASET----LEELDWC-LDQLETL-------QTRHSVSEMASNKFKRMLNR-- 309

  Fly   499 VLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDS- 562
               ||           ..:||:|.|. .|::::::.|     ..|     :.|     |.||.|
  Rat   310 ---EL-----------THLSEMSRSG-NQVSEYISNT-----FLD-----KQH-----EVEIPSP 344

  Fly   563 TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAK 627
            ||       ...:||...::|:    :||.                              |||..
  Rat   345 TQ-------KEKEKKKRPMSQI----SGVK------------------------------KLMHS 368

  Fly   628 QKVALECLSYHATASQDQTEKLTQDVIA-EAESYNLYSF-TFTDFELVDDDTCRAVLR-MFMQCN 689
            ..:...|:.....    :||:  :||:| |.|..|.:.. .|...||..:.....::. :|.:.:
  Rat   369 SSLTNSCIPRFGV----KTEQ--EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 427

  Fly   690 LVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLV 753
            |:..|:||.|.|..:::::..:|. .|.|||..||.:|.|:...:|.|..:|...||||||..:.
  Rat   428 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF 492

  Fly   754 ACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSV 817
            |...||:||.|.:|.|...|.|.||::|. :|.:|:||......:|..|..:|||.|:.:..:|:
  Rat   493 ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSL 557

  Fly   818 MKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAK 875
            .|.....:|:||::.:.........:||..:....|       .::..:|..|:..| |:|...|
  Rat   558 RKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA-DLSNPTK 621

  Fly   876 PWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD 939
            |.::..:....:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.|..||:....|
  Rat   622 PLQLYRQWTDRIMEEFFRQGDRERERGMEISP--MCDKHNA-SVEKSQVGFIDYIVHPLWETWAD 683

  Fly   940 -TFPWITPLYEGTLENRRNW--------------------QDLAEKVEMGLTWIDHDTID----- 978
             ..|....:.: |||:.|.|                    |...||.:..||..:....|
  Rat   684 LVHPDAQDILD-TLEDNREWYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGESDTEKDS 747

  Fly   979 -KPVEEFAACADEE---IKDIEFTVTTLNCNQQSQHGSEDSHTPE 1019
             ..|||..:|:|.:   .:|.|.|...|:...:.:..:|:...|:
  Rat   748 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPQ 792

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.