Protein Alignment Pde6 and Pde11a

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_006499516.1
• Gene: Pde11a / 241489
• MGIID: 3036251
• Length: 1011
• Species: Mus musculus
• Alignment Length: 1034
• Identity: 405/1034 - (39%)
• Similarity: 565/1034 - (54%)
• Gaps: 145/1034 - (14%)

  Fly    30 ASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAVTNR 94
            |||.:|...||:..|.|.|.|.      ||.|.||.|..|:        |.|
Mouse    48 ASSLRPALAGASSLAQSNAKGS------PGIGGGAGPQGSA--------HSH------------- 85

  Fly    95 SSETKLMTPTGSSS-----SPS-QSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEK 153
                  .||.|..|     ||| .|.|:...|:|.:.||:: |.|   :.::.....|.|.::|:
Mouse    86 ------PTPGGGESAGVPLSPSWASGSRGDGSLQRRASQKE-LRK---SFARSKAIHVNRTYDEQ 140

  Fly   154 PEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASS 218
                   :|.|| .|.||.::.....||....|..|:.:....:.:...:.|..|.::
Mouse   141 -------VTSRA-QEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPQYPPTAI------- 190

  Fly   219 LPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPT-NKYL 282
              :.:.||...:|.:.|:||::|::|:||:..|.:|||:.|.|:..|||.||||.:|... .|.|
Mouse   191 --DYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTL 253

  Fly   283 VAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGY 347
            |:|.|||...|.|....:..::.|:.:|:|.||.|.|.:..:.:||.:||:|.|||.|||..|||
Mouse   254 VSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGY 318

  Fly   348 KTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEY 412
            ||.::|||||.|.:|:||||||.|||......|.|.|.::.:.||.||||.|.|||||..|.:||
Mouse   319 KTKSLLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEY 383

  Fly   413 RRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQP 477
            .|::.||.:...:||||.:||.:|.|||..|:.|||||||||.|::           .||.|
Mouse   384 ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE-----------DIESP--- 434

  Fly   478 ATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLA---QIAQFVATTGQTV 539
               .:|...|||          |........|.|..:.||.:.|.|...   .||:.||:||..|
Mouse   435 ---VVKFTKSFE----------LMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVASTGLPV 486

  Fly   540 NICDVIEWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDAS 599
            |:.|.      :...|.:.|.|.     .:::||:||.|:..::|||||::|:.:|.||.|:|..
Mouse   487 NVSDA------YQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQR 545

  Fly   600 IFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYS 664
            :||||.|||||||:||.||:...|..|||.|||:.||||||.|:.:.:|.....|.......:..
Mouse   546 LFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDD 610

  Fly   665 FTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQT 729
            ..|.||.|..|....|.|||||:..:|.:|:|.|:.||||:|:||||||.|.|||||||.||.|.
Mouse   611 IHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQL 675

  Fly   730 MFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHHHFDQ 793
            |||||.|...:..:|::|||.::|.||||||||||||||||.|::|.||.|| |::|:|||||:.
Mouse   676 MFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNH 740

  Fly   794 CVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKD 858
            .||||.|||:|||..||.::|..:|:.::.:||:|||.:||::|..|.|||..|::||.....:|
Mouse   741 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVRKGDYDWSITSHRD 805

  Fly   859 LLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQV 923
            :...|:|||||:.|:.||||:..:||:||..|||:|||.|:.:|...|.|:.||.||||||::|:
Mouse   806 VFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQL 870

  Fly   924 GFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEM--------GLT---WIDHDTI 977
            .:||.||:|||:.:            |:  |.|..:.|.|..|:        .||   | :.|::
Mouse   871 EWIDSICMPLYQSI------------GS--NIRGPEFLTESTELAFFVYLNESLTTGGW-EGDSL 920

  Fly   978 -------------DKPVEEFAACADEEIKDIEFTVTT-LNCNQQ--SQHGSEDSHTPEH 1020
                         .:....|:.|..:|:..:....|| |.|..:  ..||.....|..|
Mouse   921 LLFFAGLGEGQCKTETNAGFSGCQPKEVGRVAPKKTTGLGCLPRPCQSHGGRGRQTVNH 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	77/159 (48%)
		GAF	431..619	CDD:214500	73/195 (37%)
		PDEase_I	717..950	CDD:278654	121/233 (52%)
Pde11a	XP_006499516.1	GAF	217..380	CDD:214500	78/162 (48%)
		GAF	402..568	CDD:214500	74/198 (37%)
		PDEase_I	663..885	CDD:365964	121/233 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56763
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820