Protein Alignment Pde6 and Pde10a

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_017172949.1
• Gene: Pde10a / 23984
• MGIID: 1345143
• Length: 891
• Species: Mus musculus
• Alignment Length: 966
• Identity: 272/966 - (28%)
• Similarity: 450/966 - (46%)
• Gaps: 162/966 - (16%)

  Fly    46 STAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAVTNRSSET--------KLMT 102
            |:...|..|.|:.|...|  ||..:..|  :.:...:.||::........:.|        :|..
Mouse    28 SSEEPGCLPFALKGGSKG--PALLALRN--RTDSRGQMSNDSTEGTVGSCNATGGRGQSLPQLCF 88

  Fly   103 PTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPP 167
            |.|    |..:..:..|..|       ||:.|                 :|.|.|.:.||:....
Mouse    89 PPG----PHDTKGEYGAVFQ-------RLSSA-----------------QKKEEFTRGLTDEKVK 125

  Fly   168 EALSR----LQEFIENRKPHKRPSVTSDLFQQWM--AASPTVQQKSPRSLSNSSASSLPECRRHL 226
            ..||.    |.||:..       ||:::..::|:  ..:....:.||:.:|....:::
Mouse   126 AYLSLHPQVLDEFVSE-------SVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNM------- 176

  Fly   227 MDLDEGELFMELIRDVANELDI----DVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLF 287
                :|.:: ||...:...||.    .:|.:::...:.:.|.||..:|:.. |...|...
Mouse   177 ----QGVVY-ELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFL-GECNNSLC----- 230

  Fly   288 DVTQKTALKDAVTRASAEEIIIPF-----GIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGY 347
             |.....:|:...|      :||.     |..|:..||::::.:.:::...|.||.....|::|.
Mouse   231 -VFIPPGMKEGQPR------LIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGT 288

  Fly   348 KTNAILCMPICNYEGDIIGVAQII---NKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSV 409
            :..::||:||....||:||:.::.   .|...|:...    |:....|.:..:.|...|:.....
Mouse   289 RIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQ----EVATANLAWASVAIHQVQVCRGLA 349

  Fly   410 QEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKP 474
            ::...|..||:::::.|:....::.|:..||..|:.|:..:||::|.||
Mouse   350 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVD---------------- 398

  Fly   475 NQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTV 539
                            .|.:..::.||::|.|.:...:.: ...|:..|....||..||.||:.:
Mouse   399 ----------------HKNKELYSDLFDIGEEKEGKPIFK-KTKEIRFSIEKGIAGQVARTGEVL 446

  Fly   540 NICDVIEWVRDHNQIRAEDEID-----STQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDAS 599
            ||.|.      :...|...|:|     :|:.||||||: ::..||||.|::||.:|..|:.:|.:
Mouse   447 NIPDA------YADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDEN 504

  Fly   600 IFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYS 664
            .|:.||:||.|.:|...||..........:|.:|.||||:..:.::.:.|.:        :||.:
Mouse   505 NFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMR--------FNLPA 561

  Fly   665 FTFTDFELVDDDTCR--------AVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWR 721
            ....|.||...|...        .|..:...|. .|.|::  :.|||:::||:||||.|.||||:
Mouse   562 RICRDIELFHFDIGPFENMWPGIFVYMIHRSCG-TSCFEL--EKLCRFIMSVKKNYRRVPYHNWK 623

  Fly   722 HALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTM 786
            ||:.||..|:|:|:..  ....||||..|||:|||||||||||.:|::..|.:.|||.||:||||
Mouse   624 HAVTVAHCMYAILQNN--NGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTM 686

  Fly   787 EHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDW 851
            |.|||.|.|.||..||:|||..||..:|..|::.:..||::||||:||..|....|:.:.|..:.
Mouse   687 EQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNL 751

  Fly   852 QGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKD 916
            ..:..:|.:.|:||||||:.::.|.|.|....|..:..||:.:|| |..:|..||:.||||:::|
Mouse   752 HNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKRD 815

  Fly   917 ELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWI 972
            |:|:.|:||.:.:.:|.|..|....|...||.:...:|...|:.:....|..: ||
Mouse   816 EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAM-WI 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	36/170 (21%)
		GAF	431..619	CDD:214500	54/192 (28%)
		PDEase_I	717..950	CDD:459723	104/232 (45%)
Pde10a	XP_017172949.1	GAF	<170..>354	CDD:441805	40/212 (19%)
		GAF	372..527	CDD:214500	55/194 (28%)
		PDEase_I	619..850	CDD:459723	104/233 (45%)