DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde10a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_017172949.1	Gene:	Pde10a / 23984	MGIID:	1345143	Length:	891	Species:	Mus musculus

Alignment Length:	966	Identity:	272/966 - (28%)
Similarity:	450/966 - (46%)	Gaps:	162/966 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 STAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAVTNRSSET--------KLMT 102
            |:...|..|.|:.|...|  ||..:..|  :.:...:.||::........:.|        :|..
Mouse    28 SSEEPGCLPFALKGGSKG--PALLALRN--RTDSRGQMSNDSTEGTVGSCNATGGRGQSLPQLCF 88

  Fly   103 PTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPP 167
            |.|    |..:..:..|..|       ||:.|                 :|.|.|.:.||:....
Mouse    89 PPG----PHDTKGEYGAVFQ-------RLSSA-----------------QKKEEFTRGLTDEKVK 125

  Fly   168 EALSR----LQEFIENRKPHKRPSVTSDLFQQWM--AASPTVQQKSPRSLSNSSASSLPECRRHL 226
            ..||.    |.||:..       ||:::..::|:  ..:....:.||:.:|....:::
Mouse   126 AYLSLHPQVLDEFVSE-------SVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNM------- 176

  Fly   227 MDLDEGELFMELIRDVANELDI----DVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLF 287
                :|.:: ||...:...||.    .:|.:::...:.:.|.||..:|:.. |...|...
Mouse   177 ----QGVVY-ELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFL-GECNNSLC----- 230

  Fly   288 DVTQKTALKDAVTRASAEEIIIPF-----GIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGY 347
             |.....:|:...|      :||.     |..|:..||::::.:.:::...|.||.....|::|.
Mouse   231 -VFIPPGMKEGQPR------LIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGT 288

  Fly   348 KTNAILCMPICNYEGDIIGVAQII---NKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSV 409
            :..::||:||....||:||:.::.   .|...|:...    |:....|.:..:.|...|:.....
Mouse   289 RIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQ----EVATANLAWASVAIHQVQVCRGLA 349

  Fly   410 QEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKP 474
            ::...|..||:::::.|:....::.|:..||..|:.|:..:||::|.||
Mouse   350 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVD---------------- 398

  Fly   475 NQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTV 539
                            .|.:..::.||::|.|.:...:.: ...|:..|....||..||.||:.:
Mouse   399 ----------------HKNKELYSDLFDIGEEKEGKPIFK-KTKEIRFSIEKGIAGQVARTGEVL 446

  Fly   540 NICDVIEWVRDHNQIRAEDEID-----STQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDAS 599
            ||.|.      :...|...|:|     :|:.||||||: ::..||||.|::||.:|..|:.:|.:
Mouse   447 NIPDA------YADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDEN 504

  Fly   600 IFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYS 664
            .|:.||:||.|.:|...||..........:|.:|.||||:..:.::.:.|.:        :||.:
Mouse   505 NFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMR--------FNLPA 561

  Fly   665 FTFTDFELVDDDTCR--------AVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWR 721
            ....|.||...|...        .|..:...|. .|.|::  :.|||:::||:||||.|.||||:
Mouse   562 RICRDIELFHFDIGPFENMWPGIFVYMIHRSCG-TSCFEL--EKLCRFIMSVKKNYRRVPYHNWK 623

  Fly   722 HALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTM 786
            ||:.||..|:|:|:..  ....||||..|||:|||||||||||.:|::..|.:.|||.||:||||
Mouse   624 HAVTVAHCMYAILQNN--NGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTM 686

  Fly   787 EHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDW 851
            |.|||.|.|.||..||:|||..||..:|..|::.:..||::||||:||..|....|:.:.|..:.
Mouse   687 EQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNL 751

  Fly   852 QGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKD 916
            ..:..:|.:.|:||||||:.::.|.|.|....|..:..||:.:|| |..:|..||:.||||:::|
Mouse   752 HNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKRD 815

  Fly   917 ELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWI 972
            |:|:.|:||.:.:.:|.|..|....|...||.:...:|...|:.:....|..: ||
Mouse   816 EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAM-WI 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	36/170 (21%)
		GAF	431..619	CDD:214500	54/192 (28%)
		PDEase_I	717..950	CDD:278654	104/232 (45%)
Pde10a	XP_017172949.1	GAF	196..339	CDD:376570	33/159 (21%)
		GAF	372..527	CDD:214500	55/194 (28%)
		PDEase_I	619..851	CDD:365964	104/234 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5652
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830