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Protein Alignment Pde6 and Pde4d

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006517706.1	Gene:	Pde4d / 238871	MGIID:	99555	Length:	803	Species:	Mus musculus

Alignment Length:	695	Identity:	176/695 - (25%)
Similarity:	282/695 - (40%)	Gaps:	176/695 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 FEMSVQEYRRN------------------QILLNL--ARSIFEEQNNLE----------C---LV 436
            :::|.:...||                  |:|.:|  .|:.|....||:          |   .:
Mouse   194 YDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSI 258

  Fly   437 TK--IMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATR-AIKSADSFEEKKMRNRFT 498
            .|  |..||.:.|..|.    |.:||.| ...||.:       .|| ::....|.:.|:|.||
Mouse   259 NKATITEEAYQKLASET----LEELDWC-LDQLETL-------QTRHSVSEMASNKFKRMLNR-- 309

  Fly   499 VLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDS- 562
               ||           ..:||:|.|. .|::::::.|     ..|     :.|     |.||.|
Mouse   310 ---EL-----------THLSEMSRSG-NQVSEYISNT-----FLD-----KQH-----EVEIPSP 344

  Fly   563 TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAK 627
            ||       ...:||...::|:    :||.                              |||..
Mouse   345 TQ-------KEKEKKKRPMSQI----SGVK------------------------------KLMHS 368

  Fly   628 QKVALECLSYHATASQDQTEKLTQDVIA-EAESYNLYSF-TFTDFELVDDDTCRAVLR-MFMQCN 689
            ..:...|:.....    :||:  :||:| |.|..|.:.. .|...||..:.....::. :|.:.:
Mouse   369 SSLTNSCIPRFGV----KTEQ--EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 427

  Fly   690 LVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLV 753
            |:..|:||.|.|..:::::..:|. .|.|||..||.:|.|:...:|.|..:|...||||||..:.
Mouse   428 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIF 492

  Fly   754 ACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSV 817
            |...||:||.|.:|.|...|.|.||::|. :|.:|:||......:|..|..:|||.|:.:..:|:
Mouse   493 ASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSL 557

  Fly   818 MKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAK 875
            .|.|...:|:||::.:.........:||..:....|       .::..:|..|:..| |:|...|
Mouse   558 RKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA-DLSNPTK 621

  Fly   876 PWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCD 939
            |.::..:....:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.|..||:....|
Mouse   622 PLQLYRQWTDRIMEEFFRQGDRERERGMEISP--MCDKHNA-SVEKSQVGFIDYIVHPLWETWAD 683

  Fly   940 -TFPWITPLYEGTLENRRNW--------------------QDLAEKVEMGLTW---IDHDT---I 977
             ..|....:.: |||:.|.|                    |...||.:..||.   .:.||   .
Mouse   684 LVHPDAQDILD-TLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDS 747

  Fly   978 DKPVEEFAACADEE---IKDIEFTVTTLNCNQQSQHGSEDSHTPE 1019
            ...|||..:|:|.:   .:|.|.|...|:...:.:..:|:...||
Mouse   748 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPE 792

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.