DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde6a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_666198.1	Gene:	Pde6a / 225600	MGIID:	97524	Length:	860	Species:	Mus musculus

Alignment Length:	854	Identity:	271/854 - (31%)
Similarity:	438/854 - (51%)	Gaps:	85/854 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 HKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELD 247
            |.|..|.|||.....||.         ..||         ...:..::|.|:..:|:|||...|.
Mouse    27 HYRGKVISDLLGAKEAAV---------DFSN---------YHDVNSVEESEIIFDLLRDVQENLQ 73

  Fly   248 IDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFG 312
            .:.....::..:..|..|||.|||:.:.......|..:||:|.:...|:|.:....: ||:.|..
Mouse    74 AEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDS-EIVFPLD 137

  Fly   313 IGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGC 377
            :|:.|.||.:|::.|:....:|..|...:|..|.|:|..||..||.|.: |::.:...:||.:.
Mouse   138 MGVVGHVAHSKKIANVPNTEEDEHFCDFVDNLTEYQTKNILASPIMNGK-DVVAIIMAVNKIDE- 200

  Fly   378 MEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTE 442
            ..|.:.|.||..:||.|..:.::...|..:...|.||.||||.....:|||..::|....|.:..
Mouse   201 PHFTKRDEEILLKYLNFVNLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYT 265

  Fly   443 ARELLKCERCSVFLVDLDCCEASHLEKIIEKP----NQPATRAIKSADSFEEKKMRNRFTVL-FE 502
            .|..|.|:|.||.|:|:    ....|.....|    ..||....::.|..|    .|.:.|: :.
Mouse   266 VRAFLNCDRYSVGLLDM----TKQKEFFDVWPVLMGEAPAYSGPRTPDGRE----INFYKVIDYI 322

  Fly   503 LGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNIC-----DVIEWVRDHNQIRAEDEIDS 562
            |.|:.....:..|.....  :.::.:..:||..|...||.     |..|:        .::.:|.
Mouse   323 LHGKEDIKVIPNPPADHW--ALVSGLPTYVAQNGLICNIMNAPAEDFFEF--------QKEPLDE 377

  Fly   563 T----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACK 623
            :    :.:|.|||:|.:::::|||...|:.:|.||.|.|.::.|:...|.|..:.|...||:..|
Mouse   378 SGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNK 442

  Fly   624 LMAKQKVALECLSYHATASQDQTEKL--TQDV--------------------IAEAESYNLYSFT 666
            |..::.:..:.:.||.....::.:|:  |::|                    :.:||||.:..|.
Mouse   443 LENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQGELPDAESYEINKFH 507

  Fly   667 FTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMF 731
            |:|..|.:.:..:..::|:.:..:|.:|.||.:.|.|::.|:.|.||.:.||||||..||.||||
Mouse   508 FSDLPLTELELVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMF 572

  Fly   732 AMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVM 796
            ::|.|||::|:.||||.|.::.|..|||:|||||||.:|.|:::|||.|:.:|.:|.||.:....
Mouse   573 SLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKT 637

  Fly   797 ILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEF-----DWQ---- 852
            :|..|..||||.|:...:...:..::.||::||||:|||||..|.::|:..:.     :|.
Mouse   638 LLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQEWTQYMM 702

  Fly   853 -GEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKD 916
             .:.:|:::..|||||||:|||.||||||.|||.|||.||::|||||:..|...|:.||||.:.|
Mouse   703 LEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767

  Fly   917 ELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPV 981
            ||||:||||||.:|..:|:........|||:.:|...||:.|:.||::.|..:..::.:...:..
Mouse   768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEAKMKALEEEKQKQQA 832

  Fly   982 EEFAACADE 990
            .:.||..::
Mouse   833 AKQAASGNQ 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	44/158 (28%)
		GAF	431..619	CDD:214500	47/201 (23%)
		PDEase_I	717..950	CDD:278654	116/242 (48%)
Pde6a	NP_666198.1	GAF	67..232	CDD:214500	47/167 (28%)
		GAF	254..441	CDD:214500	49/204 (24%)
		PDEase_I	558..802	CDD:278654	116/243 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930