DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde9a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_612552.1	Gene:	Pde9a / 191569	RGDID:	621035	Length:	534	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	115/385 - (29%)
Similarity:	188/385 - (48%)	Gaps:	59/385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 MAKQKVALECLS-YHATASQDQTEKLTQDVIAEAESYNL---YSF-------------TFTDFEL 672
            |.:::|.||.|. ......:...:|:.:::.|.....|.   |||             |:..: |
  Rat   123 MLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKY-L 186

  Fly   673 VDDDTCRAVLR-------------------MFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYH 718
            :..:|..|:.:                   |:....||..|.|....|.||:|.|..|||...:|
  Rat   187 LSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFH 251

  Fly   719 NWRHALNVAQTMFAML-KTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT 782
            |:||...|.|.|::|: ..|..|:| :.::||.|:.|.:||||||.|.||.:|....:.||:.|.
  Rat   252 NFRHCFCVTQMMYSMVWLCGLQEKF-SQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYN 315

  Fly   783 -TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVEN 846
             .|.:|:||......||.....|||.::.||.:|.:.:.:.:.||:||:|.:.:..::|.|.:||
  Rat   316 DISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMEN 380

  Fly   847 GEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVA-MM 910
              ||:..||...||..:::..||:|...:|.||.......:.:|:|.|.|.||.:  ..||| .|
  Rat   381 --FDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFM 441

  Fly   911 DRERKDELPK--MQVGFIDVICLPLYRVLCDTFP-----WITPLYEGTLENRRNWQDLAE 963
            ||   |::.|  .|:|||..:.:|::..:...||     .:.||:    |:|.::::|.:
  Rat   442 DR---DKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLW----ESREHYEELKQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500
		PDEase_I	717..950	CDD:278654	84/242 (35%)
Pde9a	NP_612552.1	PDEase_I	250..478	CDD:278654	82/235 (35%)
Pde9a	NP_612552.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..534
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820