Protein Alignment Pde6 and pde-6

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_001370828.1
• Gene: pde-6 / 190808
• WormBaseID: WBGene00022389
• Length: 760
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 127/553 - (22%)
• Similarity: 229/553 - (41%)
• Gaps: 71/553 - (12%)

  Fly   459 LDCCEASHLEKIIEKPNQPATRAIKS-ADSFEEKKMRNRFTVLFELGGEYQA------------- 509
            ::.|:...:.:.:.:..:..|..|:| .....|.:||.:  .|....||.:.
 Worm   240 VEICDEQRVVQYVNRAYENVTGCIRSEVIGQPESEMRRK--SLPRARGEEERRRSCDWKFIRVPF 302

  Fly   510 ANVSRPSVSELSSST--LAQIAQFVA-------TTGQTVNICDVIEWVRDHNQIRAEDEIDSTQA 565
            ||.|:....:.|::|  .|.|.:.|:       |.|....|.:|:..:||   :.|..:.:..|.
 Worm   303 ANNSQFVYMKRSNTTGDTAAIFRDVSLKSLKSQTGGIEAPISEVLTMLRD---VSARVDGEPAQT 364

  Fly   566 IL-CMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKL---MA 626
            |. .|.::::.:.   .|..||:     |.|:|...              ||.|:...:|   ..
 Worm   365 IKDAMKVLSSHEL---YAPSINR-----FRDADRIA--------------TQYYDGLIRLHHPAR 407

  Fly   627 KQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDD--TCRAVLRMFMQCN 689
            ::|.::.........|..:..:::.||....|:.|.:.|.....|.|.|.  ..:..:::|.:..
 Worm   408 QRKRSVVDAHREKRGSHGERRRVSADVKNALENDNCWKFDILHLEKVSDHHALSQVGMKVFERWK 472

  Fly   690 LVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLV 753
            :........|:|.||:||:..:|.... |||..||.:|.|.....|.:..:...:.:...:..|:
 Worm   473 VCDVLGCSDDLLHRWILSIEAHYHAGNTYHNATHAADVLQATSFFLDSPSVAVHVNESHAVAALL 537

  Fly   754 ACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMI-LNSEGN-NIFQALSPEDYR 815
            |...|||||.|..||:...|...|||||. .|.:|:||......: |....| |||.:||.|::.
 Worm   538 AAAVHDLDHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANVNIFSSLSREEFI 602

  Fly   816 SVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQ 880
            .:...:...:|:||::.:|:....|.::......:.|.:.....:|.|::...|:|..|:.|.:.
 Worm   603 QMRHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTNSLTICDMLVKCADISNPAREWGLC 667

  Fly   881 HKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKD-ELPKMQVGFIDVICLPLYRVLCDTFPWI 944
            .:.|..:.:|:|:|...||.:  ..||.|...:|.. .:|..|.||||:.....:....: |..:
 Worm   668 QRWAHRIVEEYFEQTREEKEK--GLPVTMEVFDRNTCNVPITQCGFIDMFAREAFATFTE-FAKL 729

  Fly   945 TPLYEGTLENRRNWQDLAEKVEMGLTWI-DHDT 976
            ..|.:....|...|:.:..:      |. .|:|
 Worm   730 GELSDQLESNYEKWKVMTSQ------WTPTHNT 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	36/183 (20%)
		PDEase_I	717..950	CDD:459723	66/236 (28%)
pde-6	NP_001370828.1	PAS	218..>356	CDD:441804	24/120 (20%)
		RocR	229..>280	CDD:443041	7/41 (17%)
		PDEase_I	501..736	CDD:459723	66/237 (28%)