DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and Pde9a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_036016291.1	Gene:	Pde9a / 18585	MGIID:	1277179	Length:	536	Species:	Mus musculus

Alignment Length:	413	Identity:	121/413 - (29%)
Similarity:	199/413 - (48%)	Gaps:	70/413 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   627 KQKVALECLS-YHATASQDQTEKLTQDVIAEAESYNL---YSF-------------TFTDFELVD 674
            :::|.||.|. ......:...:|:.:::.|.....|.   |||             |:..: |:.
Mouse   125 EKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKY-LLS 188

  Fly   675 DDTCRAVLR-------------------MFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNW 720
            .:|..|:.:                   |:....||..|.|....|.||:|.|..|||...:||:
Mouse   189 PETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNF 253

  Fly   721 RHALNVAQTMFAML-KTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-T 783
            ||...|.|.|::|: ..|..|:| :.::||.|:.|.:||||||.|.||.:|....:.||:.|. .
Mouse   254 RHCFCVTQMMYSMVWLCGLQEKF-SQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 317

  Fly   784 STMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGE 848
            |.:|:||......||.....|||.::.||.:|.:.:.:.:.||:||:|.:.:..::|.|.:||
Mouse   318 SPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMEN-- 380

  Fly   849 FDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVA-MMDR 912
            ||:..||...||..:::..||:|...:|.||.......:.:|:|.|.|.||.:  ..||| .|||
Mouse   381 FDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDR 443

  Fly   913 ERKDELPK--MQVGFIDVICLPLYRVLCDTFP-----WITPLYEGTLENRRNWQDLAEKVEMGLT 970
               |::.|  .|:|||..:.:|::..:...||     .:.||:    |:|.::::|.:
Mouse   444 ---DKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLW----ESREHYEELKQ------- 494

  Fly   971 WIDHDTID--KPVEEFAACADEE 991
             :| |.:.  |.|:...|.|:|:
Mouse   495 -LD-DAMKEVKAVQRVQAVAEED 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500
		PDEase_I	717..950	CDD:278654	84/242 (35%)
Pde9a	XP_036016291.1	PDEase_I	250..478	CDD:395177	82/235 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820