Protein Alignment Pde6 and Pde4b

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_006502918.1
• Gene: Pde4b / 18578
• MGIID: 99557
• Length: 736
• Species: Mus musculus
• Alignment Length: 659
• Identity: 162/659 - (24%)
• Similarity: 269/659 - (40%)
• Gaps: 133/659 - (20%)

  Fly   466 HLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGG-------EYQAANVSRPSVSELSSS 523
            |.:.:|..|......:::|        :||.||:|..|.|       ....|.|||.|:.|.|..
Mouse   160 HGDDLIVTPFAQVLASLRS--------VRNNFTLLTNLHGAPNKRSPAASQAPVSRVSLQEESYQ 216

  Fly   524 TLAQIAQFVATTGQTVNIC-DVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIG------- 580
            .||.      .|.:.::.| |.:|.::.:   |:..|:.|          |..|:::.
Mouse   217 KLAM------ETLEELDWCLDQLETIQTY---RSVSEMAS----------NKFKRMLNRELTHLS 262

  Fly   581 --------VAQLI-----NKANGVPF---TDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQK 629
                    |::.|     :|.|.|..   |..|....:...:.       ||: ....|||....
Mouse   263 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM-------TQI-SGVKKLMHSSS 319

  Fly   630 VALECLSYHA--TASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVS 692
            :....:|...  |.::|...|..:|:    ..:.|..|....:......|| .:..:|.:.:|:.
Mouse   320 LNNTSISRFGVNTENEDHLAKELEDL----NKWGLNIFNVAGYSHNRPLTC-IMYAIFQERDLLK 379

  Fly   693 QFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACL 756
            .|:|..|....:::::..:|. .|.|||..||.:|||:...:|.|..::...||||||..:.|..
Mouse   380 TFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAA 444

  Fly   757 CHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKT 820
            .||:||.|.:|.|...|.|.||::|. .|.:|:||......:|..|..:|||.|:.:..:::.|.
Mouse   445 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKM 509

  Fly   821 VESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMMTACDVSAIAKPWE 878
            |...:|:||::.:.........:||..:....|       .::..:|..|:..| |:|...|..|
Mouse   510 VIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA-DLSNPTKSLE 573

  Fly   879 VQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFP 942
            :..:....:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.|..||:....|.
Mouse   574 LYRQWTDRIMEEFFQQGDKERERGMEISP--MCDKHTA-SVEKSQVGFIDYIVHPLWETWADL-- 633

  Fly   943 WITPLYE---GTLENRRNW-QDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLN 1003
             :.|..:   .|||:.||| |.:..:           :...|::|.:......::..:|.:|.
Mouse   634 -VQPDAQDILDTLEDNRNWYQSMIPQ-----------SPSPPLDERSRDCQGLMEKFQFELTL-- 684

  Fly  1004 CNQQSQHGSEDSHTPEHQRSG-SRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHV 1067
                   ..|||..||.:..| |..|..||..:               :|   |:....|.|:.:
Mouse   685 -------EEEDSEGPEKEGEGHSYFSSTKTLCV---------------ID---PENRDSLEETDI 724

  Fly  1068 SEDMDDKSP 1076
            ....:||||
Mouse   725 DIATEDKSP 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	38/183 (21%)
		PDEase_I	717..950	CDD:278654	76/244 (31%)
Pde4b	XP_006502918.1	PDE4_UCR	166..281	CDD:375549	29/141 (21%)
		PDEase_I	405..646	CDD:365964	77/247 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910