Protein Alignment Pde6 and Pde4a

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_899668.1
• Gene: Pde4a / 18577
• MGIID: 99558
• Length: 844
• Species: Mus musculus
• Alignment Length: 1066
• Identity: 229/1066 - (21%)
• Similarity: 386/1066 - (36%)
• Gaps: 296/1066 - (27%)

  Fly   101 MTPTGSSSSPSQS-----PSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKW 160
            |.|..:.|..|.|     |.:.||:::.......|..:......|:...:.|
Mouse     1 MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSA------------- 52

  Fly   161 LTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSL------ 219
              ||:.||           |.|| ||...:|       |..|..:...|:...|..||.
Mouse    53 --ERSEPE-----------RSPH-RPIERAD-------AVDTGDRPGLRTTRMSWPSSFHGTGTG 96

  Fly   220 -PECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNK--- 280
             ...||  ::.:.|    .......:.||..       .:.||:.||         |..|::
Mouse    97 GGSSRR--LEAENG----PTPSPGRSPLDSQ-------ASPGLMLHA---------GAATSQRRE 139

  Fly   281 ---YLVAKLFDVTQKTALKDA--VTRASAEEIII-PFGIGIAGMVAQTKQMINIKEAYKDARFNC 339
               |.....:|::.||..:::  .:.|..|::|: ||...:|.:              ::.|.|.
Mouse   140 SFLYRSDSDYDMSPKTMSRNSSVASEAHGEDLIVTPFAQVLASL--------------RNVRSNF 190

  Fly   340 EIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQL 404
            .:      .||    :||.:.:...:|....:.|                            |.|
Mouse   191 SL------LTN----VPIPSNKRSPLGGPPSVCK----------------------------ATL 217

  Fly   405 FEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEK 469
            .|.:.|:         |||...||                              ||.|    ||:
Mouse   218 SEETCQQ---------LARETLEE------------------------------LDWC----LEQ 239

  Fly   470 IIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVAT 534
            :   ......|::....|.:.|:|.||     ||           ..:||:|.|. .|::::::.
Mouse   240 L---ETMQTYRSVSEMASHKFKRMLNR-----EL-----------THLSEMSRSG-NQVSEYISN 284

  Fly   535 TGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDAS 599
            |     ..|     :.|     |.||.|... ...|........:..||.:::..|:...
Mouse   285 T-----FLD-----KQH-----EVEIPSPTP-RQRPFQQPPPAAVQQAQPMSQITGLKKL----- 328

  Fly   600 IFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYS 664
                        :|...:..|..:...|               .||.:.|.|: :.....:.|..
Mouse   329 ------------VHTGSLNINVPRFGVK---------------TDQEDLLAQE-LENLSKWGLNI 365

  Fly   665 FTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQ 728
            |..:::......:| .:..:|.:.:|:.:|.||.|.:..::|::..:|. .|.|||..||.:|.|
Mouse   366 FCVSEYAGGRSLSC-IMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQ 429

  Fly   729 TMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFD 792
            :...:|.|..::...||||||..|.|...||:||.|.:|.|...|.|.||::|. .|.:|:||..
Mouse   430 STHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 494

  Fly   793 QCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG---- 853
            ....:|..|..:|||.||....:|:.|.|...:|:||::.:.........:||..:....|
Mouse   495 VGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLL 559

  Fly   854 ---EEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRER 914
               .::..:|..|:..| |:|...||.|:..:....:..|||.|||.|:.: :...|  |.|:..
Mouse   560 DNYSDRIQVLRNMVHCA-DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISP--MCDKHT 621

  Fly   915 KDELPKMQVGFIDVICLPLYRVLCD-TFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTI- 977
            . .:.|.||||||.|..||:....| ..|....:.: |||:.|:|...|.:.....|..:...:
Mouse   622 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD-TLEDNRDWYHSAIRQSPSPTLEEEPGVL 684

  Fly   978 ------DKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALG 1036
                  ||  .:|....:||.::....|..|.|.:::.....|:.....::|..:   .::.|:.
Mouse   685 SDPALPDK--FQFELTLEEEDEEDSLEVPGLPCTEETLLAPHDTRAQAMEQSKVK---GQSPAVV 744

  Fly  1037 KAVRSKLSKTLYNSMDGSKPKTSLKL------LESHVSEDMDDKSPTSPSQPQASGSMG------ 1089
            :...|...:|.  |..|: |:.|.:.      ||:.:..|:...||:.    :|.|.:|
Mouse   745 EVAESLKQETA--SAHGA-PEESAEAVGHSFSLETSILPDLRTLSPSE----EAQGLLGLPSMAA 802

  Fly  1090 -------RMSASSSTSSAGGQMVDKS 1108
                   .::|..:.|:..|...|.|
Mouse   803 EVEAPRDHLAAMRACSACSGTSGDNS 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	27/167 (16%)
		GAF	431..619	CDD:214500	30/187 (16%)
		PDEase_I	717..950	CDD:278654	79/242 (33%)
Pde4a	NP_899668.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..124		32/169 (19%)
		PDEase_I	418..659	CDD:278654	80/245 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..844		3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820