DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde3b

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_035185.2	Gene:	Pde3b / 18576	MGIID:	1333863	Length:	1099	Species:	Mus musculus

Alignment Length:	661	Identity:	154/661 - (23%)
Similarity:	250/661 - (37%)	Gaps:	141/661 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 ARELLKCERCSVFLVDLDCCEASHLEKIIEKP----NQPATRAIKSADSFEEKKMRNRFTVLFEL 503
            |..||..|.||.:  |....:.|:.|..:...    |.|.     |::.|...|.|:....|...
Mouse   423 ASSLLTNEHCSRW--DRSSGKRSYQELSVSSHGCHLNGPF-----SSNLFTIPKQRSSSVSLTHH 480

  Fly   504 GGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQI--RAEDEIDS---- 562
            .|..:|.  :.||.|.|:||:...::....|....:...|..:::...|.|  |:...:.|
Mouse   481 AGLRRAG--ALPSHSLLNSSSHVPVSAGSLTNRSPIGFPDTTDFLTKPNIILHRSLGSVSSAADF 543

  Fly   563 ------TQAILCMPIMNAQKKVIGVAQLINKANGVPFT-----DSDASIFEAFAIFCGLGIHNTQ 616
                  :.:.||....:...|.:...:    .:|....     :.|:|:|....    |.|..||
Mouse   544 HQYLRNSDSNLCSSCGHQILKYVSTCE----PDGTDHPSEKSGEEDSSVFSKEP----LNIVETQ 600

  Fly   617 MYENACKLMAKQKVALECLSYHATASQ----DQTEKLTQDVIAEAESY--NLYSFTFTDFELVDD 675
            ..|...|  |.:::.||..|:....:|    ||...|...::.:.:|.  .:.::.|..||||:.
Mouse   601 EEETMKK--ACRELFLEGDSHLMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEK 663

  Fly   676 -------DTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAM 733
                   ...:.:..:|....|:..|:||......:..::...||.:.|||..||.:|...::.:
Mouse   664 MGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYL 728

  Fly   734 --------------------------------------------LKTGKMERFMTDLEILGLLVA 754
                                                        :..|.:...:..||::.|.||
Mouse   729 TTRPIPGLPQIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVA 793

  Fly   755 CLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQC-VMILNSEGNNIFQALSPEDYRSV 817
            ...||.||.|..|||...|.:|.|:||. .|.:|:||.... .:.|:....|....|...:::..
Mouse   794 AAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRF 858

  Fly   818 MKTVESAILSTDLAMYF---KKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEV 879
            ...|..|||:|||..:|   .:.||....|.:...:|..|..:.|:|.:.:...|::..||..::
Mouse   859 RFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDL 923

  Fly   880 QHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTF-- 941
            ..:..:.:.:||::|||.| .|.|...|  .|||. ..:|.|:|..||..|..|    ||:::
Mouse   924 HLRWTEGIVNEFYEQGDEEATLGLPISP--FMDRS-SPQLAKLQESFITHIVGP----LCNSYDA 981

  Fly   942 ------PWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVT 1000
                  .|| ...||         |..|..:      |.|..|...||..: .|||.:|
Mouse   982 AGLLPGQWI-ETEEG---------DDTESDD------DDDDDDGGGEELDS-DDEETED------ 1023

  Fly  1001 TLNCNQQSQHG 1011
            .||...|.:.|
Mouse  1024 NLNPKPQRRKG 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	41/196 (21%)
		PDEase_I	717..950	CDD:278654	73/290 (25%)
Pde3b	NP_035185.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..28
		DUF1109	60..241	CDD:284050
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..423		154/661 (23%)
		Interaction with PIK3R6. /evidence=ECO:0000250	415..439		7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..590		3/23 (13%)
		PDEase_I	712..986	CDD:278654	71/280 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920