DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and Pde1a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001153054.1	Gene:	Pde1a / 18573	MGIID:	1201792	Length:	545	Species:	Mus musculus

Alignment Length:	348	Identity:	105/348 - (30%)
Similarity:	176/348 - (50%)	Gaps:	39/348 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 GIHNTQMYENACKLMAKQKVALECLSYHAT--ASQDQTEKLTQDVIAEAESYNLYSFTFTDFELV 673
            ||...:||.....::.        |:|.|.  .:..:.:|.:.||.|..|:...:|..|..:||
Mouse   128 GIFVERMYRKNYHMVG--------LTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYEL- 183

  Fly   674 DDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM-FAMLK 735
                       |.:.:|:::|:||...|..:..::...|...|  |||..||.:|.||: :.||.
Mouse   184 -----------FTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLH 237

  Fly   736 TGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILN 799
            ||.| .::|:||||.::.|...||.:|.||.|.|..:|.|.:||||. .|.:|:||......::.
Mouse   238 TGIM-HWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301

  Fly   800 SEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMM 864
            .|..||...||.:|:|.:...|...:|:||::.:|::    ::.:.|.....:|.::...: .::
Mouse   302 EEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQ----IKNIRNSLQQPEGIDRAKTM-SLI 361

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDEL-PKMQVGFID 927
            :.|.|:|..||.|::.::....:.:|||.|||.| :|.|...|:.    :||..: .:.|:||||
Mouse   362 LHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC----DRKSTMVAQSQIGFID 422

  Fly   928 VICLPLYRVLCD-TFPWITPLYE 949
            .|..|.:.:|.| |...:.||.|
Mouse   423 FIVEPTFSLLTDSTEKIVIPLIE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	3/7 (43%)
		PDEase_I	717..950	CDD:278654	81/238 (34%)
Pde1a	NP_001153054.1	Calmodulin-binding	24..44
		PDEase_I_N	77..133	CDD:369905	2/4 (50%)
		PDEase_I	218..434	CDD:365964	76/225 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010