DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde-3

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001293571.1	Gene:	pde-3 / 183981	WormBaseID:	WBGene00008443	Length:	693	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	122/557 - (21%)
Similarity:	201/557 - (36%)	Gaps:	128/557 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 GGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILC 568
            |||......|:|.:|.::.||:      .:.||
Worm   194 GGESMVVGASKPRISNITFSTV------TSATG-------------------------------- 220

  Fly   569 MPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALE 633
            :|.:.|:.         |||....:..::||            ..|...:|....|:.|..|:.:
Worm   221 LPTVPAEP---------NKARSSSYWKTEAS------------PSNNNEHETPVDLLRKISVSRK 264

  Fly   634 CLSYHATA--------SQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDT--CRAVLRMFMQC 688
            ....|...        ..|..|..|...:||..   ::||...........|  .|....:|.|.
Worm   265 ESGTHVDTVVTTIDGQRYDTRELDTDPDLAETA---VWSFPIFQMSRKHPQTILSRLTYNIFQQA 326

  Fly   689 NLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMT--------- 744
            .|...|::.......:..::.|.|..:.|||..||.:|....:.:........|:|
Worm   327 ELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLT 391

  Fly   745 ----------------DLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFD 792
                            .||::.|..|...||.||.|..|||..:.|...||||. .|.:|:||..
Worm   392 PPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAA 456

  Fly   793 QCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKK 857
            :...:||...|:..:.|.|.:.:.....|...||:|||..:|:....|.|.:.  |.|.|.|..:
Worm   457 ESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLT--EIDVQVETDR 519

  Fly   858 DLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKM 921
            .|:..:::...|:::..||:.:..:....:.:||::|||.|:.: |...|  .||| ...::.|:
Worm   520 LLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITP--YMDR-GDAQVAKL 581

  Fly   922 QVGFIDVICLPLYRVL--CDTFPWITPLYEGTL-----ENRRNWQDLAE-----KVEMGLTWIDH 974
            |..||..:..||...:  |...|.:..|....|     .|.|.|::..|     ..|..:|....
Worm   582 QDSFIAHVVSPLATAMNECGLLPILPGLDTSELIINMEHNHRKWKEQIELENGGSYEAQITCNGG 646

  Fly   975 DTIDKPVEEFAACA------------DEEIKDIEFTV 999
            ..::..:||.:|..            |.::..:.||:
Worm   647 TAVNGVIEEESASTSDSPDPRRDSPLDSDLSQVPFTI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	18/114 (16%)
		PDEase_I	717..950	CDD:278654	71/261 (27%)
pde-3	NP_001293571.1	PDEase_I	355..610	CDD:278654	70/259 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920