Protein Alignment Pde6 and pde-5

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_491544.3
• Gene: pde-5 / 183125
• WormBaseID: WBGene00016328
• Length: 728
• Species: Caenorhabditis elegans
• Alignment Length: 846
• Identity: 244/846 - (28%)
• Similarity: 405/846 - (47%)
• Gaps: 162/846 - (19%)

  Fly   142 DVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQK 206
            |...|.:..:|.|:..|                :|:.:.:      ::.:.|::| |...|::.|
 Worm     2 DDASVLKYLQENPKLVE----------------DFVVSNE------ISPETFKRW-AVRRTMKYK 43

  Fly   207 SPRSLSNSSASSLPE-----CRRHLMDLDEGE---LFMELIRDVANELDIDVLCHKIL--VNVGL 261
            :.::.::....:..|     .||.:::..:..   |:           :|...|.:::  .::.|
 Worm    44 NVKNGTSGGTGAWTEPDLSMKRRVILETSDNRTRILY-----------EITQCCGQLIGTNSIEL 97

  Fly   262 LTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMI 326
            :...|.|: |..:.|...            :..||...|..||:.|             ||  ::
 Worm    98 IVQNDEGA-FSCRKTENG------------ELKLKKVKTSKSADYI-------------QT--IV 134

  Fly   327 NI-KEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRR 390
            |. .:...:..|..::|     .|...:...:|.:..          .||...|...|..|
 Worm   135 NAGNQTIAEIHFYTQLD-----STEKSIVNAVCTWAA----------ATNYYSELYTHKQE---- 180

  Fly   391 YLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVF 455
                   |.....:.|...::.:.:..||::|||||.:..:::.::.|:|..|::|:..:|.|:|
 Worm   181 -------GSDGQDIHENIAKQRKLSNFLLDVARSIFHDIVSMDAVIIKVMNFAQKLVDADRASLF 238

  Fly   456 LVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELG-GEYQAANVSRPSVSE 519
            |||                                .|....:..:|::| |:.:...|:.....|
 Worm   239 LVD--------------------------------SKNAQIYARIFDVGTGDEEHVRVNSEGQKE 271

  Fly   520 LSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVI 579
            :.......||.:||:||:.:||.:..|      ..|...::||     |:.||||||: .:..||
 Worm   272 IRFDMSKGIAGYVASTGEGLNIENAYE------DERFNADVDSKTGYTTKTILCMPIL-IRGIVI 329

  Fly   580 GVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQD 644
            ||.|::||.:|| ||..|...||.||::|||.:|:.::|:...:...|.:||||.|:||:..:.|
 Worm   330 GVVQMVNKHDGV-FTRQDEDAFEIFAVYCGLALHHAKLYDKIRRSEQKYRVALEVLAYHSVCNAD 393

  Fly   645 QTEKLTQ----DVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDV--LCR 703
            :..||.:    :.|.|.|:.:......::.|       :.:..::|...|.:. .:.:|.  |.|
 Worm   394 EVNKLKKIEINNRIVELETIDFNGMRLSELE-------KPLYAVYMFKTLFAD-TLRFDTEDLIR 450

  Fly   704 WVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNA 768
            :||:||||||.|.||||.|..:||..|||.|.... :.| |.||.|.|.|:||||||||||.|||
 Worm   451 FVLTVRKNYRRVAYHNWAHGWSVAHAMFATLMNSP-DAF-TKLEALALYVSCLCHDLDHRGKNNA 513

  Fly   769 FQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMY 833
            :.....:|||.:|:||.||.|||:|.|.||..:|:||.::||.|||:..:..::..||:||||::
 Worm   514 YMKTMSTPLASIYSTSVMERHHFNQTVTILQQDGHNILKSLSSEDYKKTLSLIKHCILATDLALF 578

  Fly   834 FKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE 898
            |..:.....:::|..||...:|.:.|...:|||.||:.|.||||.:|.:..|::.:||:||||.|
 Worm   579 FSNKAKLNVILDNNTFDINRQEHRLLTQAVMMTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAE 643

  Fly   899 KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAE 963
            :|. ..:|:.||||::...||:|||||:..||:|.|.::...||....:.|....|.:.|::|||
 Worm   644 RLS-GKEPIPMMDRQQAHMLPQMQVGFMRGICMPCYDLIARIFPKNDKMRERCEYNAKKWEELAE 707

  Fly   964 K 964
            :
 Worm   708 E 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	26/161 (16%)
		GAF	431..619	CDD:214500	55/193 (28%)
		PDEase_I	717..950	CDD:459723	104/232 (45%)
pde-5	NP_491544.3	GAF	221..371	CDD:214500	56/189 (30%)
		PDEase_I	464..695	CDD:459723	105/233 (45%)