DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde-2

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001022705.2	Gene:	pde-2 / 176270	WormBaseID:	WBGene00011146	Length:	831	Species:	Caenorhabditis elegans

Alignment Length:	737	Identity:	196/737 - (26%)
Similarity:	326/737 - (44%)	Gaps:	162/737 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 SIFEE----QNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKS 484
            |||::    .|||..|::.|:.||::..:.|..:|||.|.|
Worm   166 SIFDQFLCLTNNLSALISCIIAEAKKNTEAEDYAVFLHDED------------------------ 206

  Fly   485 ADSFEEKKM--RNRFTVL-----FELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNIC 542
                 .|:|  .|..|:|     |::|                     ..|...||:|.:|:||.
Worm   207 -----NKQMVLFNNETMLMTGKKFDMG---------------------YGIVGKVASTMRTMNIR 245

  Fly   543 DVIEWVRDHNQIRAEDEIDSTQA--ILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFA 605
            ||......:.:|   ||..|.:|  ::..|::::...:|||..|.||.||  |:..|....:.|:
Worm   246 DVSRCPFFNEEI---DEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKENG--FSRHDEKYIKRFS 305

  Fly   606 IFCGLGIHNTQMYENACKLMAKQ--------------KVALECLSYHATASQDQTEKLTQDVIAE 656
            .|....|        |..::|||              |:..|    .|...:....:|..|.:.:
Worm   306 YFVANSI--------AHAILAKQIEEVRTRIHMVEEFKIQGE----DAVIEEVDIMRLVNDPLRD 358

  Fly   657 AE--SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHN 719
            ..  |.|...|:|....:.::...||.:..|........:::....|...||.|...||||.|||
Worm   359 WRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVPYHN 423

  Fly   720 WRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKT--ESPLAILYT 782
            |.||..|....:..|:|..:.|.::|:|.|.||:||||||:|||||.|:||.::  ::||::||:
Worm   424 WSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQKTPLSVLYS 488

  Fly   783 T--STMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVE 845
            |  |.:|.|||.|.:.:|..|..:|.:.|...|:|:::.|:...||:||::.:.:|:.....::.
Worm   489 TEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISAHLRKQERIKTMIS 553

  Fly   846 NGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMM 910
            .|......:.:..|:| ::|||.|:|..||.:....::|:.:..|||.||||| |||..:|:.||
Worm   554 EGYNPMSFDHRYLLMC-LVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLE-LQLGVKPLEMM 616

  Fly   911 DRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMG-LTWIDH 974
            ||... .:|.:|:.|:..|.:|::::|....|      ||        :..:|.::.. |.|:
Worm   617 DRTNA-YVPTVQIDFLFKIGVPVFQLLASVVP------EG--------RTTSEAIDANHLCWV-- 664

  Fly   975 DTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAV 1039
                        ..|||:::......||...:     .|:.....:.|      ::|.......:
Worm   665 ------------ALDEEVRNNPSATNTLEYLR-----DENLERRIYDR------VRKQDPRAAEI 706

  Fly  1040 RSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSP--TSPSQPQASG------SMGRMSASSS 1096
            .||..:.:|  .:||.|:|. .:|: |..:..|.|..  .|..|.|::|      |:.::.:.:|
Worm   707 ASKRFEPVY--ANGSVPQTQ-DILD-HRFDGYDKKYQIGCSGGQNQSNGKQQQIRSLQKIRSKTS 767

  Fly  1097 TSSA-------GGQMVDKSKKR 1111
            ...|       ||.:...|.:|
Worm   768 EDDALLKPMDNGGSVAASSTRR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	47/196 (24%)
		PDEase_I	717..950	CDD:278654	86/236 (36%)
pde-2	NP_001022705.2	GAF	177..322	CDD:214500	51/207 (25%)
pde-2	NP_001022705.2	PDEase_I	421..657	CDD:278654	89/252 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3659
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870