Protein Alignment Pde6 and pde-2

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_001022705.2
• Gene: pde-2 / 176270
• WormBaseID: WBGene00011146
• Length: 831
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 196/737 - (26%)
• Similarity: 326/737 - (44%)
• Gaps: 162/737 - (21%)

  Fly   424 SIFEE----QNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKS 484
            |||::    .|||..|::.|:.||::..:.|..:|||.|.|
 Worm   166 SIFDQFLCLTNNLSALISCIIAEAKKNTEAEDYAVFLHDED------------------------ 206

  Fly   485 ADSFEEKKM--RNRFTVL-----FELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNIC 542
                 .|:|  .|..|:|     |::|                     ..|...||:|.:|:||.
 Worm   207 -----NKQMVLFNNETMLMTGKKFDMG---------------------YGIVGKVASTMRTMNIR 245

  Fly   543 DVIEWVRDHNQIRAEDEIDSTQA--ILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFA 605
            ||......:.:|   ||..|.:|  ::..|::::...:|||..|.||.||  |:..|....:.|:
 Worm   246 DVSRCPFFNEEI---DEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKENG--FSRHDEKYIKRFS 305

  Fly   606 IFCGLGIHNTQMYENACKLMAKQ--------------KVALECLSYHATASQDQTEKLTQDVIAE 656
            .|....|        |..::|||              |:..|    .|...:....:|..|.:.:
 Worm   306 YFVANSI--------AHAILAKQIEEVRTRIHMVEEFKIQGE----DAVIEEVDIMRLVNDPLRD 358

  Fly   657 AE--SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHN 719
            ..  |.|...|:|....:.::...||.:..|........:::....|...||.|...||||.|||
 Worm   359 WRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVPYHN 423

  Fly   720 WRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKT--ESPLAILYT 782
            |.||..|....:..|:|..:.|.::|:|.|.||:||||||:|||||.|:||.::  ::||::||:
 Worm   424 WSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQKTPLSVLYS 488

  Fly   783 T--STMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVE 845
            |  |.:|.|||.|.:.:|..|..:|.:.|...|:|:::.|:...||:||::.:.:|:.....::.
 Worm   489 TEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISAHLRKQERIKTMIS 553

  Fly   846 NGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMM 910
            .|......:.:..|:| ::|||.|:|..||.:....::|:.:..|||.||||| |||..:|:.||
 Worm   554 EGYNPMSFDHRYLLMC-LVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLE-LQLGVKPLEMM 616

  Fly   911 DRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMG-LTWIDH 974
            ||... .:|.:|:.|:..|.:|::::|....|      ||        :..:|.::.. |.|:
 Worm   617 DRTNA-YVPTVQIDFLFKIGVPVFQLLASVVP------EG--------RTTSEAIDANHLCWV-- 664

  Fly   975 DTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAV 1039
                        ..|||:::......||...:     .|:.....:.|      ::|.......:
 Worm   665 ------------ALDEEVRNNPSATNTLEYLR-----DENLERRIYDR------VRKQDPRAAEI 706

  Fly  1040 RSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSP--TSPSQPQASG------SMGRMSASSS 1096
            .||..:.:|  .:||.|:|. .:|: |..:..|.|..  .|..|.|::|      |:.::.:.:|
 Worm   707 ASKRFEPVY--ANGSVPQTQ-DILD-HRFDGYDKKYQIGCSGGQNQSNGKQQQIRSLQKIRSKTS 767

  Fly  1097 TSSA-------GGQMVDKSKKR 1111
            ...|       ||.:...|.:|
 Worm   768 EDDALLKPMDNGGSVAASSTRR 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	47/196 (24%)
		PDEase_I	717..950	CDD:459723	86/236 (36%)
pde-2	NP_001022705.2	GAF	177..322	CDD:214500	51/207 (25%)
		PDEase_I	421..648	CDD:459723	86/235 (37%)