Protein Alignment Pde6 and pde-1

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_493343.1
• Gene: pde-1 / 173200
• WormBaseID: WBGene00011433
• Length: 664
• Species: Caenorhabditis elegans
• Alignment Length: 620
• Identity: 148/620 - (23%)
• Similarity: 248/620 - (40%)
• Gaps: 168/620 - (27%)

  Fly   458 DLDCCEASHLEKIIEKPNQPATRAIKSADSFEE----KKMRNRFTVLFEL-GGEYQAANVSRPSV 517
            |.:|.|        ::|..|::...||.|:...    :|:|   .:|.:| .|:....::.|
 Worm   122 DDNCQE--------KEPTSPSSSRKKSYDNAPALESLEKLR---YILHQLNSGQLPLEDLKR--- 172

  Fly   518 SELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPI--MNAQKKVIG 580
                :...|.:....|...:|..|||..:   |..::..|...|..:..|....  .||.||
 Worm   173 ----NIEYAALVLETAYMDETRRICDEDD---DLAEVTPETVPDEVREWLAATFTRQNAGKK--- 227

  Fly   581 VAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQ 645
                           .|...|::.|.....||    .:|   ||..||:| ::|      ....:
 Worm   228 ---------------RDKPKFKSVANAIRTGI----FFE---KLFRKQQV-VQC------PIPPE 263

  Fly   646 TEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAV----LRMFMQCNLVSQFQIPYDVLCRWVL 706
            ..:|.::|.         :::|:.|:|.:.....|:    ..:|.:...:.:|::|...|..::.
 Worm   264 IAELMKEVC---------TWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLS 319

  Fly   707 SVRKNY----RPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNN 767
            ::...|    .|  |||..||.:|.|:...||....:...:.|||:|.:|...|.||.:|.|..|
 Worm   320 ALEVGYSKHNNP--YHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTN 382

  Fly   768 AFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLA 831
            .|..:::|..|:||. .|.:|:||...|..::..:..||...|:.::|:.:...|...:|:||::
 Worm   383 NFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMS 447

  Fly   832 MYF---KKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFD 893
            .:|   |...:.|.|.|       |.:|...|| :::.|||:|..||||.:..:..:.|.:|||.
 Worm   448 THFMQIKTMKSMLSLPE-------GIDKNKALC-LIVHACDISHPAKPWNLHERWTEGVLEEFFR 504

  Fly   894 QGDLE-KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLC------------------D 939
            ||||| .:.|...|  :.||... .:...|:||||.|..|. .|:|                  .
 Worm   505 QGDLEASMGLPYSP--LCDRHTV-HVADSQIGFIDFIVEPT-MVVCGELLVKMVEPLVSLPPTDS 565

  Fly   940 TFP-------------WITPL-------------------YEGTL-----------ENRRNWQDL 961
            .||             .::||                   |.|.|           ||:.:|::.
 Worm   566 LFPPSVDGGDDKSPSNALSPLPDLRNSSTSPSSIRRIPLNYAGKLDIPTPWMKFLHENKAHWKER 630

  Fly   962 AEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIE 996
            |.|.|.          ::.::| ||.|:...|.:|
 Worm   631 AAKEEE----------ERKIKE-AAEAEAAAKQVE 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	33/167 (20%)
		PDEase_I	717..950	CDD:459723	82/287 (29%)
pde-1	NP_493343.1	PDEase_I_N	191..248	CDD:462497	17/84 (20%)
		PDEase_I	332..560	CDD:459723	77/239 (32%)